Fig. 7
From: Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
a Part of a TMA immunohistochemical double stained for senescence by nuclear anti-H3K9me3 (blue) and membranous anti-E-Cadherin (red) in rectal cancer. Arrows indicating cell-in-cell events. Zoomed images of the tissue micro array, b a cell-in-cell event in which both involved cells are senescent, c a cell-in-cell event in which both involved cells are not senescent, d engulfed cell is senescent (asterisk marks the cell in the tissue micro array) and (e) a cell-in-cell event in which only the engulfing cell is senescent. f Distribution of senescence in the engulfing and in the engulfed cell in all observed cell-in-cell events. Differences were analyzed by the Student’s t-test