Table 2 Univariate and multivariate analysis of overall survival according to Cox’s proportional hazards model
From: Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation
Rectal cancer | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Variable | Hazard ratio | 95% C.I. | p | Hazard ratio | 95% C.I. | p |
T stage (T4 [n = 21] v. T1/T2/T3 [n = 121]) | 0.596 | 0.272–1.306 | 0.196 | 0.555 | 0.254–1.213 | 0.140 |
N stage (N+ [n = 101] v. N0 [n = 41]) | 0.732 | 0.4–1.337 | 0.309 | 0.777 | 0.433–1.395 | 0.398 |
M stage (M+ [n = 23] v. M0 [n = 119]) | 5.233 | 2.682–10.208 | < 0.001 | 4.495 | 2.469–8.183 | < 0.001 |
Grading (3 + 4 [n = 27] v. 1 + 2 [n = 115]) | 1.329 | 0.674–2.619 | 0.411 | – | – | – |
Gender (female [n = 34] v. male [n = 108]) | 0.796 | 0.416–1.522 | 0.491 | – | – | – |
Age (> 58 years [n = 72] v. < 58 years [n = 70]) | 1.772 | 1.002–3.132 | 0.049 | 1.635 | 0.942–2.839 | 0.081 |
Cell-in-cell > 3/mm2 [n = 31] v. ≤ 3/mm2 [n = 111] | 1.237 | 0.617–2.477 | 0.549 | – | – | – |
Senescence > 328/mm2 [n = 89] v. ≤ 328/mm2 [n = 53] | 0.895 | 0.116–6.928 | 0.915 | – | – | – |
Cell-in-cell > 3/mm2 and senescence > 328/mm2 [n = 26] v. others [n = 116] | 2.849 | 0.332–24.434 | 0.340 | 2.623 | 1.46–4.713 | 0.001 |