Fig. 7

Gene Ontology (GO) analysis of genetic interactors. a Genes annotated by the Saccharomyces genome database (SGD) as interacting either physically or genetically with ADE3, ECM14, or URA3 were analyzed by Gene Ontology (GO). Little overlap is observed between GO terms for these three genes. The heatmap represents P-values for enrichment of genes within particular GO classifications. Arrowhead next to heatmap scale bar indicates 0.05. Top 25 GO terms are shown for ECM14 only. b GO analysis for genes identified by whole-genome sequencing as being mutated in the indicated synthetic lethals, and for which PROVEAN analysis surpassed a threshold of − 4.0. GO terms are mapped to those identified in the SGD for ADE3, ECM14, and URA3 interactors. All others are listed at ND, not determined