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Table 1 Analysis of isolated synthetic lethals

From: Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase

Name pSLS1(−) rescue (% red colonies) pSLS-ECM14 rescue (% red colonies) # of causative mutations Possible causative mutationa
WT 0 0
SL1 3.9 2.7 3 ND
SL2 0 0 ≥4 ND
SL4 0 0 ≥4 ND
SL6 16.8 (1/6) 20.6 (1/5) 1 SHM2 D219N (ade3 SL)
SL7 21.0 (1/5) 18.5 (1/5) 1 SHM2 D219N (ade3 SL)
SL8 7.7 0 3  
SL9 0 1.5 ≥4 ND
SL10 0 0 ≥4 ND
SL11 10.5 (1/10) 10.6 (1/10) 2 SHM2 G403R (ade3 SL)
SL12 0 0 ≥4  
SL13 0 0.8 ≥4 SHM1 P252S (ade3 SL)
SL14 6.9 8.9 2 SHM2 G252D (ade3 SL)
SL15 15.0 9.1 2 ND
SL18 0 0 ≥4 ND
SL20 5.0 0 3 ND
SL21 15.1 7.6 2 ND
  1. a ND not determined