Fig. 7
Expression of immune regulatory factor genes in the rat LSEC and KC transcriptomes. The genes were associated with the terms cytokine receptor activity (GO:0004896), cytokine receptor binding (GO:0005126), complement receptor activity (GO:0004875), and complement activation (GO:0006956). a. Volcano-plot illustrating differently expressed genes. Blue dots: significantly higher expression in LSECs; red dots: significantly higher expression in KCs; gray dots: not significantly different between LSECs and KCs. Significance level: FDR ≤ 0.05 and |log2 fold change| ≥ 1. b-e. Expression of selected genes in LSECs and KCs transcriptome associated with cytokine receptor activity (b), cytokine activity (c), complement receptor activity (d), and regulators of complement activation (e). Each blue dot represents abundance, corresponding to log2 expression values (RPKM+ 1), in an LSEC sample and each red dot represents abundance in a KC sample. *Significantly higher in LSECs, #significantly higher in KCs. Significance level: FDR ≤ 0.05 and |log2 fold change| ≥ 1