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Table 2 Analysis of different linkers using ProtParam server

From: Designing a chimeric subunit vaccine for influenza virus, based on HA2, M2e and CTxB: a bioinformatics study

  Linker Sequence II of the fusion protein Aliphatic Index Gravy
Flexible linkers LF1 (G8) GGGGGGGG 35.08 74.92 −0.455
LF2 (G4S) GGGGS 32.45 76.15 −0.459
LF3 (G4S)2 GGGGSGGGGS 33.82 74.12 −0.459
LF4 GSAGSAAGSGEF 29.26 74.92 −0.425
LF5 KESGSVSSEQLAQFRSLD 34.65 77.08 −0.487
LF6 EGKSSGSGSESKST 32.26 72.57 −0.537
Rigid Linkers LR1 EAAAK 31.55 77.80 −0.456
LR2 A (EAAAK)2AA 30.06 77.68 −0.419
LR3 (XP)n = APAPAP 35.88 77.38 −0.440
LR4 (XP)n = EPEPEP 35.63 75.74 .527
LR5 (XP)n:KPKPKP 28.63 75.74 −0.533
LR6 (XP)n: GPGP 30.32 76.57 −0.470