TY - JOUR AU - Leung, Jacqueline M. AU - Nagayasu, Eiji AU - Hwang, Yu-Chen AU - Liu, Jun AU - Pierce, Phillip G. AU - Phan, Isabelle Q. AU - Prentice, Robin A. AU - Murray, John M. AU - Hu, Ke PY - 2020 DA - 2020/02/28 TI - A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers JO - BMC Molecular and Cell Biology SP - 8 VL - 21 IS - 1 AB - TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX contains two tubulin-binding domains: a partial P25α and the DCX/doublecortin domain. Orthologues are found in apicomplexans and their free-living relatives Chromera and Vitrella. SN - 2661-8850 UR - https://doi.org/10.1186/s12860-020-0249-5 DO - 10.1186/s12860-020-0249-5 ID - Leung2020 ER -