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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers

Fig. 5

TgDCX bridges TgCPH1 to tubulin. a Deconvolved wide-field images of Xenopus S3 cells expressing mCerulean3FP-TgCPH1, mCherryFP-TgDCX and EGFP-α-tubulin. Inset: a control Xenopus S3 cell that expresses mCerulean3FP-TgCPH1 but not TgDCX (also see Additional file 2: Figure S1). CPH1 on its own does not bind to microtubules in Xenopus cells, but is recruited to the microtubules by TgDCX. b RHΔku80Δhx (“WT”) and TgDCX knockout (ΔDCX) parasites expressing mCherryFP tagged TgCPH1. CPH1 localizes to daughters (arrows) and adult conoids (arrowheads) regardless of the presence of TgDCX

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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