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Table 10 Significant associations of SLC7A5 mRNA with offspring body composition up 5 years

From: Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

   

Model 1

 

Model 2

 

Body composition

variables

N

beta

(95% CI)

P

beta

(95% CI)

P

SLC7A5

1 year

Weight (g)

40

558.89 (44.09; 1073.68)

0.034

298.86 (−328.20; 925.92)

0.340

 

Fat mass (g)

40

168.56 (−21.09; 358.20)

0.080

143.14 (−94.10; 380.38)

0.229

 

Lean mass (g)

40

390.32 (22.79; 757.87)

0.038

155.72 (− 283.62; 595.07)

0.477

3 years

Weight (g)

36

971.58 (−47.11; 1990.26)

0.061

562.71 (− 730.36; 1855.78)

0.382

 

Fat mass (g)

22

492.81 (10.88; 974.73)

0.045

362.20 (−207.62; 932.02)

0.198

 

Lean mass (g)

22

541.14 (− 537.77; 1620.05)

0.308

127.01 (− 1125.52; 1379.54)

0.833

5 years

Weight (g)

34

1318.28 (− 256.63; 2893.18)

0.098

608.94 (− 1346.48; 2564.37)

0.529

 

Fat mass (g)

23

539.54 (− 169.71; 1248.79)

0.129

437.27 (− 309.48; 1184.02)

0.234

 

Lean mass (g)

23

895.84 (− 722.26; 2513.94)

0.263

166.60 (− 1605.80; 1939.00)

0.846

  1. Linear regression analyses: summary of significant associations between regulated placental expression of SLC7A5 mRNA and offspring body composition at 1 year, 3 and 5 years of age is shown. ΔCq-values for SLC7A5 mRNA expression were used. Beta (95% CI) values with P-values < 0.05 are given in bold. Abbreviations: N Sample numbers analyzed, P P-value
  2. Model 1: unadjusted
  3. Model 2: adjusted for respective baseline levels of maternal blood plasma Tau and Trp at week-15 of gestation (P15) before treatment, sex, and group. Adjusted additionally for breastfeeding status (fully, partially breastfeeding/formula) from 1 year