Control | Intervention | Control | Intervention | P-values regression | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(Con-F + Con-M) | (N3-F + N3-M) | Con-F | Con-M | N3-F | N3-M | Treatment | Sex | Interaction | Con-M vs Con-F | N3-M vs N3-F | N3-F vs Con-F | N3-M vs Con-M | |||||||||||||
N | MRE | N | MRE | N | MRE | N | MRE | N | MRE | N | MRE | ||||||||||||||
% | ± SD | % | ± SD | % | ± SD | % | ± SD | % | ± SD | % | ± SD | ||||||||||||||
microRNA | |||||||||||||||||||||||||
miR-30d | 16 | 100 ± 30 | 19 | 97 ± 33 | 9 | 100 ± 35 | 7 | 97 ± 29 | 10 | 94 ± 38 | 9 | 98 ± 31 | 0.620 | 0.756 | 0.652 | 0.899 | 0.596 | 0.506 | 0.997 | ||||||
miR-320 | 18 | 100 ± 64 | 19 | 108 ± 61 | 10 | 100 ± 70 | 8 | 92 ± 59 | 10 | 111 ± 68 | 9 | 95 ± 57 | 0.415 | 0.515 | 0.650 | 0.903 | 0.438 | 0.369 | 0.831 | ||||||
miR-100 | 19 | 100 ± 34 | 18 | 107 ± 40 | 11 | 100 ± 33 | 8 | 108 ±37 | 9 | 115 ± 41 | 9 | 107 ± 42 | 0.558 | 0.917 | 0.389 | 0.594 | 0.492 | 0.313 | 0.812 | ||||||
miR-99a | 19 | 100 ± 51 | 19 | 149 ± 70 | 11 | 100 ± 41 | 8 | 142 ± 63 | 10 | 186 ± 70 | 9 | 164 ± 79 | 0.001 | 0.511 | 0.026 | 0.039 | 0.266 | < 0.001 | 0.452 | ||||||
mRNA | |||||||||||||||||||||||||
mTOR | 20 | 100 ± 22 | 21 | 122 ± 34 | 11 | 100 ± 13 | 9 | 119 ± 21 | 10 | 136 ± 38 | 11 | 129 ± 28 | 0.008 | 0.330 | 0.098 | 0.062 | 0.649 | 0.003 | 0.441 | ||||||
SLC7A5 | 20 | 100 ± 71 | 21 | 122 ± 70 | 11 | 100 ± 60 | 9 | 183 ± 104 | 10 | 165 ± 80 | 11 | 170 ± 90 | 0.052 | 0.019 | 0.012 | 0.001 | 0.955 | 0.002 | 0.704 | ||||||
SLC6A6 | 20 | 100 ± 60 | 20 | 53 ± 25 | 11 | 100 ± 40 | 9 | 109 ± 67 | 9 | 57 ± 22 | 11 | 54 ± 18 | < 0.001 | 0.945 | 0.807 | 0.825 | 0.900 | < 0.001 | < 0.001 | ||||||
Protein | |||||||||||||||||||||||||
LAT1 | 8 | 100 ± 25 | 10 | 77 ± 17 | 4 | 100 ± 25 | 4 | 71 ± 17 | 5 | 74 ± 21 | 5 | 58 ± 16 | 0.010 | 0.004 | 0.341 | 0.010 | 0.085 | 0.014 | 0.183 |