Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

Table 5 Correlations of placental free estradiol-17ß (E2), testosterone (T), and E2/T ratio with levels of target microRNA and mRNA

Group		*mTOR*			*SLC6A6*			*SLC7A5*			*MiR-99a*
Group		E2	T	E2/T	E2	T	E2/T	E2	T	E2/T	E2	T	E2/T
All offspring	Rs	0.124	0.014	0.048	−0.071	−0.081	0.030	0.242	−0.022	0.124	0.107	−0.071	0.092
	P	0.441	0.931	0.766	0.665	0.619	0.855	0.127	0.893	0.441	0.523	0.673	0.583
	N	41	41	41	40	40	40	41	41	41	38	38	38
Male offspring	Rs	0.251	−0.056	0.197	−0.147	−0.098	−0.161	0.465	0.084	0.356	0.061	−0.360	0.446
	P	0.286	0.816	0.405	0.535	0.682	0.498	0.039	0.724	0.123	0.815	0.155	0.073
	N	20	20	20	20	20	20	20	20	20	17	17	17
Female offspring	Rs	0.029	0.183	−0.131	0.093	−0.301	0.429	−0.019	0.147	−0.316	0.027	0.432	−0.343
	P	0.902	0.427	0.571	0.696	0.198	0.059	0.933	0.526	0.163	0.909	0.050	0.128
	N	21	21	21	20	20	20	21	21	21	21	21	21
Con: All offspring	Rs	0.247	−0.150	0.338	−0.120	−0.053	−0.102	0.235	−0.176	0.116	0.140	−0.267	0.186
	P	0.295	0.528	0.145	0.613	0.825	0.668	0.319	0.458	0.627	0.567	0.269	0.446
	N	20	20	20	20	20	20	20	20	20	19	19	19
N3: All offspring	Rs	0.073	0.110	−0.026	−0.104	−0.035	−0.038	0.204	−0.051	0.238	0.096	0.011	0.065
	P	0.754	0.634	0.911	0.663	0.885	0.875	0.375	0.827	0.300	0.694	0.966	0.792
	N	21	21	21	20	20	20	21	21	21	19	19	19

N Number of analyzed individual samples, P P-value for the correlation, E2 Free estradiol-17ß, E2/T Free estradiol-17ß / testosterone ratio, T Testosterone, Rs Spearman-rho correlation coefficient. Bold data represent significant correlations (P < 0.05)

ISSN: 2661-8850