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Table 7 Amino acid analyses of placenta and umbilical cord plasma

From: Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

Placenta

Amino acid

levels

(μmol/g

protein)

Control group

n-3 LCPUFA intervention group

P-values regression

Con-F (n = 11)

Con-M (n = 8)

N3-F (n = 10)

N3-M (n = 11)

Treatment

Sex

Interaction

Con-M

vs

Con-F

N3-M

vs

N3-F

N3-F

vs

Con-F

N3-M

vs

Con-M

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Tau

387.01

(269.08–485.66)

317.50

(239.14–402.34)

335.87

(243.70–589.43)

277.91

(246.19–382.32)

0.919

0.266

0.962

0.430

0.432

0.916

0.973

His

5.42

(4.03–8.00)

4.90

(3.40–7.53)

4.60

(3.23–10.60)

4.24

(3.78–6.63)

0.605

0.508

1.000

0.644

0.636

0.706

0.729

Val

5.04

(4.34–7.33)

4.54

(3.49–7.14)

5.08

(3.52–9.59)

4.83

(3.35–5.40)

0.798

0.216

0.536

0.654

0.194

0.800

0.532

Met

2.54

(0.90–3.28)

2.03

(1.76–3.63)

3.19

(2.13–4.11)

2.85

(1.45–3.87)

0.142

0.868

0.323

0.543

0.424

0.084

0.762

Tyr

6.25

(5.43–8.90)

5.06

(3.88–8.75)

6.12

(3.82–12.00)

5.40

(4.10–6.03)

0.640

0.193

0.545

0.625

0.183

0.930

0.448

Ile

6.16

(5.66–7.64)

5.58

(4.11–7.77)

5.11

(3.95–11.33)

5.62

(3.75–6.74)

0.840

0.271

0.736

0.605

0.308

0.932

0.705

Leu

4.94

(4.44–7.06)

4.47

(3.36–6.09)

3.98

(3.29–8.88)

4.04

(3.13–5.44)

0.806

0.212

0.648

0.590

0.229

0.885

0.620

Phe

4.85

(4.27–7.17)

4.31

(3.42–5.92)

4.26

(3.24–9.41)

4.25

(3.30–5.33)

1.000

0.172

0.652

0.502

0.202

0.752

0.743

Trp

2.74

(2.37–3.42)

2.37

(1.68–3.30)

2.68

(1.65–4.74)

2.34

(1.86–2.94)

0.957

0.115

0.397

0.608

0.090

0.576

0.513

Umbilical Cord plasma

Amino acid levels

(μmol/L)

Control group

n-3 LCPUFA intervention group

P-values regression

Con-F (n = 8)

Con-M (n = 8)

N3-F (n = 9)

N3-M (n = 9)

Treatment

Sex

Interaction

Con-M

vs

Con-F

N3-M

vs

N3-F

N3-F

vs

Con-F

N3-M

vs

Con-M

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Median (25th - 75th)

Tau

570.00

(384.13–1078.83)

465.15

(294.07–814.45)

504.40

(360.95–586.15)

764.20

(547.35–910.70)

0.473

0.292

0.076

0.586

0.049

0.451

0.077

His

122.10

(109.15–144.20)

125.80

(109.25–133.10)

121.10

(109.25–144.30)

125.80

(110.40–143.50)

0.969

0.686

0.980

0.764

0.777

0.965

0.992

Val

107.80

(91.77–121.78)

111.55

(98.60–128.73)

125.10

(90.45–135.20)

107.30

(104.45–114.70)

0.725

0.467

0.327

0.230

0.877

0.345

0.653

Met

38.40

(29.70–52.80)

32.20

(30.53–35.68)

31.80

(27.05–40.15)

32.80

(27.10–38.50)

0.224

0.204

0.269

0.097

0.859

0.104

0.929

Tyr

96.60

(75.35–120.28)

94.25

(85.60–117.60)

121.90

(91.35–132.75)

94.50

(89.30–98.00)

0.335

0.636

0.142

0.494

0.167

0.087

0.680

Ile

81.60

(67.50–100.15)

90.70

(66.78–110.25)

88.20

(73.15–100.20)

83.80

(73.30–97.35)

0.804

0.527

0.602

0.420

0.919

0.852

0.593

Leu

57.20

(50.08–62.35)

56.80

(47.38–74.45)

59.40

(48.65–66.25)

53.60

(51.05–61.20)

0.637

0.543

0.810

0.554

0.784

0.873

0.616

Phe

79.45

(68.53–82.78)

76.40

(72.88–85.80)

80.40

(78.65–94.75)

83.00

(77.15–87.30)

0.091

0.978

0.776

0.863

0.832

0.164

0.325

Trp

155.70

(123.30–181.75)

148.95

(131.80–158.00)

149.10

(135.80–209.60)

151.80

(142.65–167.20)

0.236

0.968

0.526

0.670

0.634

0.205

0.713

  1. Amino acid data are summarized as median (25th centile - 75th centile) for the analyzed groups (Con-F and Con-M, female and male offspring of the control group, respectively; N3-F and N3-M, female and male offspring of the intervention group, respectively). The p-values for Treatment and Sex come from linear regression models fit to the amino acid data without a Sex-Group Interaction term. The p-values for the Interaction and pairwise group comparisons (Con-M vs Con-F, N3-M vs N3-F, N3-F vs Con-F, N3-M vs Con-M) are from regression models including a Sex-Group Interaction term. All regression models were adjusted for the respective baseline (P15) maternal plasma levels. Median (25th - 75th) values of comparisons with p-values < 0.05 are shown in bold
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BMC Molecular and Cell Biology

ISSN: 2661-8850

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