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Table 9 Significant associations of placental expression with offspring body composition at birth

From: Fetal sex modulates placental microRNA expression, potential microRNA-mRNA interactions, and levels of amino acid transporter expression and substrates: INFAT study subpopulation analysis of n-3 LCPUFA intervention during pregnancy and associations with offspring body composition

   

Model 1

 

Model 2

 

Body composition variables

N

beta

(95% CI)

P

beta

(95% CI)

P

mTOR

Placental weight (g)

41

−67.32 (− 145.04; 10.41)

0.088

−66.64 (− 155.76; 22.48)

0.138

BW/PW ratio

41

1.04 (0.10; 1.99)

0.032

1.00 (−0.09; 2.08)

0.071

Birthweight (g)

41

143.51 (−126.16; 413.19)

0.288

181.39 (− 126.51; 489.29)

0.240

Weight/length ratio

41

1.42 (−3.56; 6.41)

0.567

2.41 (− 3.25; 8.08)

0.394

Fat mass (g)

39

55.21 (−47.34; 157.75)

0.282

50.10 (−64.37; 164.58)

0.380

Lean mass (g)

39

86.93 (−133.42; 307.29)

0.429

120.67 (−133.03; 374.36)

0.341

miR-99a

Placental weight (g)

38

10.58 (−35.86; 57.03)

0.647

25.94 (−29.17; 81.05)

0.346

BW/PW ratio

38

−0.44 (−0.99; 0.12)

0.118

−0.76 (−1.40;− 0.13)

0.019

Birthweight (g)

38

−122.37 (− 272.82; 38.08)

0.108

−144.99 (−325.89; 35.91)

0.113

Weight/length ratio

38

−2.65 (−5.36; 0.07)

0.056

−2.84 (−6.12; 0.44)

0.088

Fat mass (g)

36

−15.20 (77.53; 47.13)

0.623

−25.65 (−97.65; 46.35)

0.473

Lean mass (g)

36

−95.99 (−225.10; 33.13)

0.140

−104.34 (−258.65; 49.97)

0.178

  1. Linear regression analyses: summary of significant associations of regulated placental expression of mTOR mRNA and miR-99a with offspring body composition at birth is shown. ΔCq-values for mRNA and microRNA expression of respective genes were used. Beta (95% CI) values with P-values < 0.05 are given in bold. Abbreviations: BW Birthweight, N Sample numbers analyzed, P P-value, PW Placental weight
  2. Model 1: unadjusted
  3. Model 2: adjusted for respective baseline levels of maternal blood plasma Tau and Trp at week-15 of gestation (P15) before treatment, sex, and group