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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells

Fig. 5

Schematic representation of the STAU2/CHK1 regulatory loop. CHK1 is well known for its role in cell cycle arrest and DNA repair following single-stranded DNA damage. In unstressed cells, CHK1 is involved in DNA replication, DNA repair and cell cycle arrest. Our results suggest that CHK1 positively controls the amount of STAU2 via inhibition of caspases. In turn, STAU2 expression positively regulates the amount of CHK1 protein, likely via the posttranscriptional regulation of CHK1 mRNA [10], linking STAU2 to cell cycle arrest and DNA repair. In addition to its role on CHK1 regulation, STAU2 may control the posttranscriptional regulation of multiple mRNAs coding for proteins involved in DNA repair, cell proliferation and DNA replication pathways. This figure was created with PowerPoint (Microsoft Office Professionnel Plus 2016)

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