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Fig. 6 | BMC Molecular and Cell Biology

Fig. 6

From: Genotype-determined EGFR-RTK heterodimerization and its effects on drug resistance in lung Cancer treatment revealed by molecular dynamics simulations

Fig. 6

Average center-of-mass distance of interfacial atom pairs along the MD trajectory for EGFR- RTK heterodimers (smoothed by moving-averaging), with the mean for each curve shown as a dashed line. (a) Comparison between WT EGFR-c-Met and L858R-c-Met dimers. (b) Comparison between WT EGFR-ErbB2 and L858R- ErbB2 dimers. (c) Comparison between WT EGFR-IGF-1R and L858R- IGF-1R dimers. (d) Comparison between L858R-c-Met and L858R-T790M-c-Met dimers. (e) Comparison between L858R -ErbB2 and L858R-T790M-ErbB2 dimers. (f) Comparison between L858R-IGF-1R and L858R-T790M- IGF-1R dimers

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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