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Fig. 11 | BMC Molecular and Cell Biology

Fig. 11

From: Effect of Voacamine upon inhibition of hypoxia induced fatty acid synthesis in a rat model of methyln-nitrosourea induced mammary gland carcinoma

Fig. 11

Effect of VOA /TMX therapy on hypoxia-induced metabolic reprogramming of serum amino acids. After MNU administration, hypoxia developed in the cancer cells, which enhanced the glycolytic pathways. As a result of this, amino acid metabolism was reprogrammed. Due to the increase in biosynthesis of amino acids like alanine, threonine, tyrosine, leucine, isoleucine, and glutamate, excess polypeptides are formed to be incorporated into the plasma membrane of rapidly dividing cells. Glutamate also acts as substrates in fatty acid synthesis. G1(normal control receives normal saline 2 ml/kg, p.o.); G2 (toxic control receives MNU 50 mg/kg, i.p); G3(MNU 50 mg/kg, i.p. + VOA 1 mg/kg, s.c.); G4 (MNU 50 mg/kg, i.p. + VOA 2 mg/kg, s,c.); G5 (MNU 50 mg/kg, i.p. + TMX 8 mg/kg, p.o.); G6 (MNU 50 mg/kg,i.p. + VOA 1 mg/kg, s.c. + TMX 1 mg/kg s.c.) and G7 (dummy control receives 3% DMSO solution s.c)

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