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Fig. 6 | BMC Molecular and Cell Biology

Fig. 6

From: Cell-in-cell phenomenon: leukocyte engulfment by non-tumorigenic cells and cancer cell lines

Fig. 6

Ring-like structures surrounding ingested leukocytes are formed by many different proteins. All images result from co-incubation of peripheral blood mononuclear cells with BEAS-2B as host cells for 4 h. They are representative of > 150 CIC structures analysed. The images depict β-catenin, p-ezrin, FAT, fibronectin, β-integrin and vinculin staining. The proteins are targeted by specific primary antibodies and all stained with Alexa Fluor 488 secondary antibodies. Leukocytes were live stained with CyTRAK orange before co-incubation. DAPI is used to stain the nuclei. Scale bars indicate 10 μm. Arrows indicate ring-like structures

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