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Fig. 4 | BMC Molecular and Cell Biology

Fig. 4

From: The 3D nuclear conformation of the major histocompatibility complex changes upon cell activation both in porcine and human macrophages

Fig. 4

a-b Analysis of LPS/IFNγ activation effects on MHC gene-to-gene 3D distances in porcine and human macrophages. Cumulative frequency graphs of the normalized center-to-center distances between MHC: (i) class I-class II [(SLA-1)-(SLA-DRA); (HLA-A)-(HLA-DRA); (ii) class II-class III [(SLA-DRA)-TNFα; (HLA-DRA)-TNFα]; and (iii) class II-class III [(SLA-1)-TNFα; (HLA-A)-TNFα]. Pairwise comparisons (p-values) of cumulative 3D distance distributions in resting and activated macrophages (Student’s t-test) are indicated in each graph

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BMC Molecular and Cell Biology

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