Fig. 7
Modeling the relative positions or survival zones (SZs) in resting and activated macrophages of three loci of the MHC whose positions are spatially linked. The loci are SLA-1/HLA-A (class I) in green, TNFα (class III) in blue, and SLA-DRA/HLA-DRA in red. The mathematical approach makes it possible to determine the specific area (SZ) in which each locus moves in resting and activated macrophage nuclei. These SZ are represented by colored dotted circles. The radii (Rg, Rb and Rr) of the SZs are indicated for each locus. All the different locus positions (X,Y) are reconstructed inside survival zones. The Python module, Seaborn, is used for 2D kernel density estimation of reconstructed points (https://seaborn.pydata.org/index.html)