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Fig. 4 | BMC Molecular and Cell Biology

Fig. 4

From: MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail

Fig. 4

Nuclear sequestration reduces MDMX activity to suppress p53 protein expression. A MDM2487/487 MEF cells were treated with empty vector (EV), MDMX or NLS-tagged MDMX lentiviral constructs for 48 h prior to immunostaining using an anti-MDMX antibody, and DAPI nuclear staining. B MDM2487/487 MEFs were treated with empty vector (EV), MDMX, or NLS-tagged MDMX lentiviral constructs for 48 h prior to lysis and immunoblotting

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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