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Fig. 9 | BMC Molecular and Cell Biology

Fig. 9

From: Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles

Fig. 9

Diffusion of mitochondria-related vesicles of A11 cells in the homograft tumor microenvironment. (a) Transfer of mitochondria-related vesicles from MitoB LT Red-labeled A11 cells (A11-Mito LT Red) to P29-EGFP cells in a syngeneic tumor model. Upper panels. Area without A11-MitoB LT Red cells. Lower panels. Area with A11-MitoB LT Red cells. Note that red-colored vesicles diffused from A11-MitoB LT Red cells toward the upper right and localized within EGFP-P29 cells in the area surrounded by a dotted line. Scale bars: 10 μm and 20 μm for the rightmost panels and other panels, respectively. (b) Transfer of mitochondria-related vesicles from mitochondria of MitoB LT Red-labeled A11 cells (A11-MitoB LT Red) to CAFs. Upper panels. Area without A11-MitoB LT Red cells. Lower panels. Area with A11-Mito LT Red cells. Note that red-colored vesicles were released from A11-Mito LT Red cells and localized within α-SMA-positive CAFs in the areas surrounded by a dotted line. Scale bars: 10 μm and 50 μm for the rightmost panels and other panels, respectively

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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