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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis

Fig. 3

TUG1 served as a miR-216a-3p sponge in HASMCs. A StarBase v2.0 predicted the complementary sequences between TUG1 and miR-216a-3p. B The luciferase activity was measured in HASMCs co-introduced with WT/MUT-TUG1 and miR-216a-3p/miR-NC using the dual-luciferase luciferase reporter assay (ANOVA). C MiR-216a-3p expression was measured in whole blood samples of childhood asthma patients and healthy subjects (t-test). D MiR-216a-3p expression was examined in HASMCs stimulated with different concentrations of PDGF-BB (ANOVA). E The correlation between TUG1 level and miR-216a-3p expression was analyzed in whole blood samples of childhood asthma patients. F TUG1 expression was determined in HASMCs (Control) or HASMCs treated with PDGF-BB, PDGF-BB + pcDNA, or PDGF-BB + TUG1 (ANOVA). G The level of miR-216a-3p was examined in HASMCs or HASMCs treated with PDGF-BB, PDGF-BB + si-NC, PDGF-BB + si-TUG1, PDGF-BB + pcDNA, or PDGF-BB + TUG1 (ANOVA). *P < 0.05

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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