Table 1 Substrate specificity
Substrate | Relative activity |
|---|---|
dThd | 100 |
Trifluorothymidine (TFT) | 104.5 |
Azidothymidine (AZT) | 55.0 |
Fluorothymidine (FLT) | 43.5 |
α-dThd | <  0.01 |
Stavudine (D4T, 2′,3′.didehydro-2′,3′-dideoxythymidine) | 6.4 |
dUrd | 106.1 |
5-fluorodeoxyuridine (5FdU) | 128.9 |
2′-deoxy-2′-fluoro-arabinofuranosyl-5-methyluracil (FMAU) | 82.6 |
D-FMAU | 96.2 |
L-FMAU | 34.6 |
2′-deoxy-2′-fluoro-arabinofuranosyl-5-iodouracil (FIAU) | 60.4 |
Uridine | 1.7 |
Cytidine | <  0.01 |
dCyd | < 0.01 |
dAdo | < 0.01 |
dGuo | < 0.01 |