Fig. 2

(A) Conservation of Receptor Binding Domain (RBD) of SARS-CoV-2 with its close relatives, SARS-CoV and Bat RaTG13. The blue colored region shows RBD and the yellow highlighted region within RBD is the Receptor Binding Motif (RBM). The mutated residues are highlighted in light blue and substitutions are marked below. Non-conserved residues are highlighted in grey color. Interacting residues are marked with black asterisk and the mutated interactions are in red asterisk symbol. (B) The carton model representation of SARS-CoV-2 RBM highlighting mutated interacting residues and most frequent mutations (red color) in RBM. (C) Maximum Likelihood Phylogenetic tree of 494 SARS-CoV-2 isolates containing RBD mutations. The outer circle represents the RBD mutations