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Fig. 8 | BMC Molecular and Cell Biology

Fig. 8

From: The absence of the autoimmune regulator gene (AIRE) impairs the three-dimensional structure of medullary thymic epithelial cell spheroids

Fig. 8

The top 10 biological process involved in spheroid profile comparing AIREWT vs. AIRE−/−. Functional annotation for modulated down A or upregulated B mRNAs in spheroids. The functional categories were identified by using DAVID genome database platform according to GO biological processes (BP). The rank is based on the enrichment score, which represents mean p-value. Only those mRNA-groups yielding < 0.05 Benjamini corrected p-value and contained at least five mRNAs are considered to be significant (DAVID Bioinformatics Resources Platform 6.8 Database, score < 0.05)

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