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Fig. 10 | BMC Molecular and Cell Biology

Fig. 10

From: Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway

Fig. 10

GluOC promotes the expression of PTHrP and IL-8 in MDA-MB-231 cells by activating the TGF-β/SMAD3 pathway. After SIS3 and GluOC were added, the expression of the PTHrP and IL-8 genes was detected by qRT–PCR. The results represent at least three independent experiments, and the data are presented as the mean ± SD (n = 3). *P < 0.05 and **P < 0.01, vs. the control group (con = control); $P < 0.05, $$P < 0.01 vs. the GluOC 40 ng/mL group; &P < 0.05, &&P < 0.01 vs. the GluOC 100 ng/mL group; #P < 0.05, ##P < 0.01 vs. the GluOC 160 ng/mL group. IL8: GluOC, uncarboxylated osteocalcin; IL-8: interleukin-8; PTHrP: parathyroid hormone related protein

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BMC Molecular and Cell Biology

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