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Fig. 8 | BMC Molecular and Cell Biology

Fig. 8

From: Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway

Fig. 8

GluOC induces the expression of MMP2, MMP13 and VEGF in MDA-MB-231 cells by promoting phosphorylation of SMAD3. a Western blotting was used to detect the content of MMP2. The protein expression level was quantified densitometrically with ImageJ software. b GluOC promoted the expression of MMP13 and VEGF in MDA-MB-231 cells via the TGF-β/SMAD3 pathway. The results represent at least three independent experiments, and the data are presented as the mean ± SD (n = 3). *P < 0.05 and **P < 0.01, vs. the control group (con = control); $P < 0.05, $$P < 0.01 vs. the GluOC 40 ng/mL group; &P < 0.05, &&P < 0.01 vs. the GluOC 100 ng/mL group; #P < 0.05, ##P < 0.01 vs. the GluOC 160 ng/mL group

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