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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p

Fig. 3

Expression and transfection of ACTA2-AS1 and miR-532-5p in TNBC cells. A Significant downregulation of ACTA2-AS1 and upregulation of miR-532-5p were observed in the TNBC cells. ***P < 0.001 compared with normal cells. B The luciferase activity of WT-ACTA2-AS1 was significantly suppressed by the overexpression of miR-532-5p and enhanced by miR-532-5p silencing. C, D The transfection of oe-ACTA2-AS1 significantly enhanced ACTA2-AS1 (C) and inhibited miR-532-5p (D), while the transfection of miR-532-5p mimic reversed the inhibition of miR-532-5p and showed an insignificant effect on ACTA2-AS1. ***P < 0.001 compared with control, ##P < 0.01, nsP > 0.05 compared with oe-ACTA2-AS1

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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