Fig. 3

The best docked pose obtained by HDOCK and HAWKDOCK. A Top docked model complex between p37 UBX from human and p97 N-D1 from human. B The key residues involved in interaction site between p37 UBX and p97 N domain. C Interatomic interactions between p97 N-domain bound to the UBX domain of either p47 (left) or p37 (right) calculated by Arpeggio. The p97-p47 complex was obtained from PDB code: 1S3S, and the p97-p37 complex is from the best docked model obtained by HDOCK and HAWKDOCK. Small grey dashed lines indicate hydrophobic interactions. White dashed lines indicate π-stacking interactions. Blue and thick white dashed lines indicate aromatic-amide interactions. Red and orange dashed lines indicate polar interactions. Residues highlighted in red indicate that the interaction or residue itself is not conserved across cofactors