Table 2 The interacting residues between p97 and p37 determined by MM/GBSA
Key residues of p37 UBX domain | Key residues of p97 N domain | ||
|---|---|---|---|
Residue | Binding Free Energy (kcal/mol) | Residue | Binding Free Energy (kcal/mol) |
PHE(304) | -5.77 | PHE(52) | -7.46 |
LEU(269) | -4.52 | TYR(110) | -4.21 |
LEU(322) | -3.45 | ARG(53) | -3.17 |
VAL(325) | -3.74 | PRO(106) | -2.86 |
GLN(260) | -2.18 | TYR(143) | -2.72 |
ASN(306) | -1.41 | ARG(262) | -2.13 |
ARG(262) | -1.28 | ILE(70) | -1.48 |