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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: Activated TRPA1 plays a therapeutic role in TMZ resistance in glioblastoma by altering mitochondrial dynamics

Fig. 5

Effect of TMZ and a TRPA1 agonist and inhibitor on mitochondrial fission and fusion protein expression. Western blot assay showing the levels of the mitochondrial fusion proteins optic atrophy 1 (OPA1) and Mitofusin 2 (MFN2) (A) and the mitochondrial fission protein dystrophin-related protein 1 (DRP1) (B) in U251 cells after treatment with TMZ and a TRPA1 agonist and inhibitor. Western blot assay showing the levels of OPA1, MFN2 (C), and DRP1 (D) in SHG-44 cells after treatment with TMZ and a TRPA1 agonist and inhibitor. GAPDH was used as an internal reference. Cropped blots are displayed, and the expression level was quantified by densitometry with ImageJ software. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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