Fig. 5
From: The role of proteoglycan form of DMP1 in cranial repair
The differential transcriptional level at defect sites in the WT and S89G-DMP1 mice. A Heatmap of the analysis profiles of defect sites between the WT and S89G-DMP1 groups. B Volcano plot analysis of differential genes at defect sites in the two groups. KEGG analysis (C) and gene ratio analysis (D) displayed the downregulated signaling pathways in the S89G-DMP1 mice. E Weaker immunoactivity of IL-17, NLRP3 and TNF-α was observed in the cranial defects in the S89G-DMP1 mice. Scale bars = 100 µm. F RT‒qPCR quantification of inflammatory signaling molecules in the defect sites. *P < 0.05, n = 6