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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression

Fig. 3

Transfection efficiency evaluation in CCLP1 and HuCCT1 cells (A). miR-451 was dramatically overexpressed by the transfection of miR-451 mimic and silenced by the transfection of miR-451 inhibitor. The biological function of miR-451 evaluation in CCLP1 and HuCCT1 cells. B The proliferation of CCLP1 and HuCCT1 cells was significantly promoted by miR-451 knockdown and suppressed by the overexpression of miR-451. C The upregulation of miR-451 dramatically inhibited the migration of CCLP1 and HuCCT1 cells, while its downregulation remarkably enhanced the cell migration of cholangiocarcinoma. D The upregulation of miR-451 dramatically inhibited the invasion of CCLP1 and HuCCT1 cells, while its downregulation remarkably enhanced the cell invasion of cholangiocarcinoma. ***P < 0.001

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