Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression

Table 1 Association between miR-451 expression and clinical features of patients

	Total (n = 159)	miR-451 in tissues		P value	Total (n = 159)	miR-451 in serum		P value
	Total (n = 159)	Low (n = 83)	High (n = 76)	P value	Total (n = 159)	Low (n = 82)	High (n = 77)	P value
Age				0.566				0.593
< 60	82	41	41		84	45	39
≥ 60	77	42	35		75	37	38
Gender				0.883				0.347
Male	89	46	43		91	44	47
Female	70	37	33		68	38	30
TNM stage				0.014				0.022
I-II	95	42	53		97	43	54
III-IV	64	41	23		62	39	23
Differentiation				0.196				0.262
Well-moderate	92	44	48		94	45	49
Poor	67	39	28		65	37	28
LNM				0.015				0.042
Negative	104	47	57		103	47	56
Positive	55	36	19		56	35	21
location				0.297				0.373
Intrahepatic	81	39	42		83	40	43
Extrahepatic	78	44	34		76	42	34

ISSN: 2661-8850