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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis

Fig. 1

Overexpression of ARNTL2 contributes to the progression of NSCLC patients and the proliferation of NSCLC cells. A The mRNA expression of ARNTL2 was analyzed in LUAD (n = 483) and normal (n = 347) tissues based on the TCGA database p < 0.05. B Overall and disease-free survival was analyzed for LUAD patients who were divided into ARNTL2 high and low expression group. n = 335 per group. p = 0.00011 and p = 0.018. C RT-qPCR analysis of ARNTL2 in H1299 cells transfected with Ctrl and ARNTL2 overexpressing lentivirus. **p < 0.01. D and E Cell proliferation was determined by CCK8 (D) and colony formation (E) assay in H1299 cells transfected with Ctrl and ARNTL2 overexpressing lentivirus. **p < 0.01. F RT-qPCR analysis of ARNTL2 in A549 cells transfected with siNC, siARNTL2#1 and siARNTL2#2. **p < 0.01. G and H Cell proliferation was determined by CCK8 (G) and colony formation (H) assay in A549 cells transfected with siNC, siARNTL2#1 and siARNTL2#2. **p < 0.01

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