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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455

Fig. 2

The effects of circ-ATL1 on VSMC viability. A RT-qPCR analysis of circ-ATL1 and linear ATL1 expression after RNase R treatment in VSMCs. Data are presented as mean ± SD. ***P < 0.001 vs NC. n = 3. B FISH analysis was used to show the expression and subcellular localization of circ-ATL1 in VSMCs both healthy and IA patients. C ATL1 gene and circ-ATL1 genomic loci. D RT-qPCR analysis of circ-ATL1 expression in VSMCs transfected with siRNA against circ-ATL1 (si-circ-ATL1). Results are presented as mean ± SD. ***P < 0.001 versus NC. n = 3. E The effects of circ-ATL1 on VSMC proliferation were assessed using the CCK8 assay. Results are presented as mean ± SD. ***P < 0.001 versus NC. n = 3. (F and G) The effects of circ-ATL1 on VSMC migration were examined using the Transwell® migration assay. Results are presented as mean ± SD. ***P < 0.001 versus NC. n = 6

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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