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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455

Fig. 5

Upregulation of SIRT5 or miR-455 inhibition reverses the inhibitory effects of circ-ATL1 silencing on VSMC migration and proliferation. A The effects of circ-ATL1 on VSMC proliferation were detected using the CCK8 assay. Results are presented as mean ± SD. ***P < 0.001 versus NC. n = 3. B and C The effects of circ-ATL1 on VSMC migration were determined using the Transwell® migration assay. Results are presented as mean ± SD. ***P < 0.001 versus NC. ###P < 0.001 vs. si-circ-ATL1. n = 3. D Contractile protein (SM-MHC, SM-α actin, and SM22) expression levels were measured in VSMCs transfected with si-circ-ATL1 by WB analysis. n = 3. E–G Quantification of relative protein expression levels. Results are presented as mean ± SD. ***P < 0.001 versus NC. ###P < 0.001 vs. si-circ-ATL1. H WB analysis of MMP-3 and MMP-2 expression levels in VSMCs transfected with si-circ-ATL1. n = 3. H and J Quantification of relative protein expression levels. Results are presented as mean ± SD. ***P < 0.001 versus NC. ###P < 0.001 vs. si-circ-ATL1

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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