Fig. 3

Bioinformatic analyses of DEGs induced by NAC. The gene expression bioinformatics analysis was performed using data obtained from RNA-seq of 2 group different cells after 7 days culturing. A GO analysis revealed that the DEGs centered on the main BP of ECM rganization and collagen fiber organization; the main MF of ECM structural constituent, integrin binding and collagen binding; the main CC of ECM and basement membrane. B The heatmap of the DEGs. C KEGG enrichment analysis indicated that DEGs focused on the PI3K/AKT signaling [30,31,32]. D A signaling network illustrated the DEGs concentrated in the integrin-related PI3K/AKT pathway