The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway

Table 1 GO analysis of the low methylation expression gene from the GSE47359 data

Category	Term	Count	PValue
GOTERM_CC_DIRECT	GO:0000790 ~ nuclear chromatin	4	0.005055271
GOTERM_BP_DIRECT	GO:0042493 ~ response to drug	3	0.011057299
GOTERM_BP_DIRECT	GO:0031668 ~ cellular response to extracellular stimulus	2	0.029690877
GOTERM_MF_DIRECT	GO:0003713 ~ transcription coactivator activity	3	0.030570734
GOTERM_BP_DIRECT	GO:0048646 ~ anatomical structure formation involved in morphogenesis	2	0.031939077
GOTERM_BP_DIRECT	GO:0045944 ~ positive regulation of transcription from RNA polymerase II promoter	5	0.043516788
GOTERM_CC_DIRECT	GO:0005667 ~ transcription factor complex	3	0.053312753
GOTERM_CC_DIRECT	GO:0090575 ~ RNA polymerase II transcription factor complex	2	0.058856003
GOTERM_BP_DIRECT	GO:0050680 ~ negative regulation of epithelial cell proliferation	2	0.099183706
GOTERM_BP_DIRECT	GO:0035914 ~ skeletal muscle cell differentiation	2	0.099183706

After the GO analysis of the low methylation expression, the functions of these hypomethylated genes were explored in several important cell processes, including repressor, secreted, and signaling (Table 1)

ISSN: 2661-8850