Fig. 3

Structural analysis of Derived ^A−allele DNA- SOX2 ^(HMG) complex. A Topological model for SOX2 ^(HMG) binding to derived ^A−allele DNA shown as semi-transparent surface and ribbons. B The zoomed image illustrates the interface between the residues of SOX2 ^(HMG) and corresponding nucleotides. Hydrogen bonds are shown by black dotted lines with calculated distances in Å. C Schematic diagram depicts interactions between derived^A−allele DNA- SOX2 ^(HMG) complex. Nucleotides (red) are interacting with amino acid residue (green) through hydrogen bonds (dotted lines) and Vander walls (solid lines). The DNA strands are displayed as orange. Cyan color shows the nucleotide variant in the Derived DNA binding site. Images were obtained from DNAproDB