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Fig. 4 | BMC Molecular and Cell Biology

Fig. 4

From: Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions

Fig. 4

Dynamic stability and residual flexibility of DNA–protein complexes along the course of 100 ns simulation. A, B The RMSD graphs of both complexes throughout the simulation explaining their stability and equilibration nature. In comparison with ancestral T-allele DNA-SOX2 (violet) complex (B), derived A-allele DNA-SOX2 (blue) complex (A) appears to be well stabilized. The x-axis shows time in nanoseconds while y-axis show RMSD in Å. C RMSF plots for each trajectory file. The x-axis shows total number of residues while y-axis show RMSF in Å. D RMSF plots for interacting residues of both complexes. The x-axis shows the interacting residues while y-axis show RMSF in Å. Violet color depict ancestral T-allele DNA-SOX2 complex whereas blue color depict derived A-allele DNA-SOX2 complex

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