Fig. 5

Radius of gyration (RoG) analysis. A, B RoG plot calculated for derived A-allele DNA-SOX2 (blue) and ancestral T-allele DNA-SOX2 (violet) complexes during the 100 ns simulation. The x-axis shows total number of frames while y-axis shows Rg in Å. C, D Structural superposition of derived A-allele DNA-SOX2 and ancestral T-allele DNA-SOX2 PDBs at different time points. Grey, blue and magenta colors represent 0 ns, 60 ns and 100 ns