Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions

Table 2 DNA binding residues of SOX2-HMG box reported previously (experimentally determined) and in the present study

	Remenyi et.al. 2003 DNA-HMG box		Present study A-allele DNA- HMG box		Present study T-allele DNA- HMG box
Sr. No	Interacting residues	SSEs	Interacting residues	SSEs	Interacting residues	SSEs
1	ARG43	L1	ARG43	L1	ARG43	L1
2	ASN46	L2	ASN46	L1	-	-
3	ARG53	H1	-	-	-	-
4	ASN68	H2	ASN68	H2	ASN68	H2
5	SER69	H2	-	-	SER69	H2
6	SER72	H2	-	-	-	-
7	LYS73	H2	LYS73	H2	-	-
8	TYR110	L3	-	-	TYR110	L3
9	ARG111	L3	-	-	-	-
10	ARG113	L3	ARG113	L3	-	-
11	ARG114	L3	ARG114	L3	ARG114	L3
12	LYS115	L3	LYS115	L3	-	-
13	-	-	ALA47	H1	-	-
14	-	-	ARG56	H1	ARG56	H1
15	-	-	-	-	PHE48	H1
16	-	-	-	-	MET49	H1

The table highlights the differential binding of HMG box of SOX2 with A-allele containing DNA and T-allele containing DNA in terms of amino acid residues and SSEs involved in docked complex. Experimentally determined amino acid residues and SSEs are also given for the reference purpose (Remenyi et.al. 2003)
SSEs Secondary structure elements, L Loop, H Helix

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