Fig. 4
From: Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines
TUDCA prevent increase in BiP expression induced by cytokines + IL6 but not CHOP expression and Bax/Bcl2 ratio in INS-1E cells. Cells were exposed to IL-6 (IL6) or untreated (Ctrl). After 24 h cells were exposed to TUDCA in the absence (TUDCA) or in the presence of pre-treatment with IL-6 (IL6 + TUDCA). Cells also were exposed to IL-1β and IFN-γ (Cyto) or not (-). Expression of BiP A and CHOP B and Bax/Bcl-2 C was evaluated by RT-qPCR. The bar plot shows the mean values obtained in three independent experiments normalized by Rn18s and control by method 2-ΔΔCT. One-way ANOVA followed by Sidak’s correction. **p < 0,001 vs Ctrl