Table 5 the docking result of CYP4F2 in both native and mutant form by HADDOCK webserver. Amino acids in bold are amino acids of CYP4F2 which are identified as important in interaction with VK1.
Complex structure | Amino acids in interaction with Vitamin K | ∆∆G (Kcal/mol) |
|---|---|---|
Native | Val397, Phe327, Glu328, Leu128, Leu504, Ser399, Tyr125, His236, Phe127, Phe124, Ile398 | -10.00 ± 0.07 |
V433M | His236, Val397, Pro396, Ser323, Met66, Leu504, Pro502, Phe60, His327, Val67, Trp59 | -8.5 ± 0.31 |