Skip to main content


Protein degradation and cell death

Protein degradation and cell death

Section edited by Xuejun Jiang

This section will consider submissions on cellular disease mechanisms, protein degradation, autophagy and cell death.

  1. Content type: Research article

    Dasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases. Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leu...

    Authors: Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos and Markus Rehm

    Citation: BMC Cell Biology 2018 19:28

    Published on:

  2. Content type: Research article

    Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was ...

    Authors: Sayilaxi Jieensinue, Hong Zhu, Guangcheng Li, Keli Dong, Meiting Liang and Yayue Li

    Citation: BMC Cell Biology 2018 19:21

    Published on:

  3. Content type: Research article

    Apoptosis, the most well-known type of programmed cell death, can induce in a paracrine manner a proliferative response in neighboring surviving cells called apoptosis-induced proliferation (AiP). While having...

    Authors: Ahlima Roumane, Kevin Berthenet, Chaïmaa El Fassi and Gabriel Ichim

    Citation: BMC Cell Biology 2018 19:11

    Published on:

  4. Content type: Research article

    Endophytes have proven to be an invaluable resource of chemically diverse secondary metabolites that act as excellent lead compounds for anticancer drug discovery. Here we report the promising cytotoxic effect...

    Authors: Mytre Koul, Ashok Kumar, Ramesh Deshidi, Vishal Sharma, Rachna D. Singh, Jasvinder Singh, Parduman Raj Sharma, Bhahwal Ali Shah, Sundeep Jaglan and Shashank Singh

    Citation: BMC Cell Biology 2017 18:26

    Published on:

    The Erratum to this article has been published in BMC Cell Biology 2017 18:27

  5. Content type: Research Article

    Autophagy is an inducible autodigestive process that allows cells to recycle proteins and other materials for survival during stress and nutrient deprived conditions. The kinase ULK1 is required to activate th...

    Authors: Wenjia Gan, Caiyun Zhang, Ka Yu Siu, Ayano Satoh, Julian A. Tanner and Sidney Yu

    Citation: BMC Cell Biology 2017 18:22

    Published on:

  6. Content type: Research article

    Vascular endothelial dysfunction is the closely related determinant of ischemic heart disease (IHD). Endothelial dysfunction and ischemia/reperfusion injury (IRI) have been associated with an increase in micro...

    Authors: Qi Zhang, Man Shang, Mengxiao Zhang, Yao Wang, Yan Chen, Yanna Wu, Minglin Liu, Junqiu Song and Yanxia Liu

    Citation: BMC Cell Biology 2016 17:25

    Published on:

  7. Content type: Research article

    In mammalian cells, ASPL is involved in insulin-stimulated redistribution of the glucose transporter GLUT4 and assembly of the Golgi apparatus. Its putative yeast orthologue, Ubx4, is important for proteasome ...

    Authors: Louise Madsen, Karen Molbæk, Ida B Larsen, Sofie V Nielsen, Esben G Poulsen, Peter S Walmod, Kay Hofmann, Michael Seeger, Chen-Ying Chien, Rey-Huei Chen, Franziska Kriegenburg and Rasmus Hartmann-Petersen

    Citation: BMC Cell Biology 2014 15:31

    Published on:

  8. Content type: Research article

    Cullins belong to a family of scaffold proteins that assemble multi-subunit ubiquitin ligase complexes to recruit protein substrates for ubiquitination via unique sets of substrate adaptor, such as Skp1 or Elo...

    Authors: Wananit Wimuttisuk, Mark West, Brittney Davidge, Kebing Yu, Arthur Salomon and Jeffrey D Singer

    Citation: BMC Cell Biology 2014 15:28

    Published on:

  9. Content type: Research article

    Diabetes and particularly high blood glucose levels are implicated in neurodegeneration. One of the hallmarks of neurodegeneration is protein aggregation. We investigated the presence of protein aggregation in...

    Authors: Fatemeh Talaei, Veroniek M Van Praag, Mahdi H Shishavan, Sjoerd W Landheer, Henk Buikema and Robert H Henning

    Citation: BMC Cell Biology 2014 15:1

    Published on:

  10. Content type: Research article

    Regulation of anoikis in human intestinal epithelial cells (IECs) implicates differentiation state-specific mechanisms. Human IECs express distinct repertoires of integrins according to their state of differen...

    Authors: Marco Beauséjour, Sonya Thibodeau, Marie-Josée Demers, Véronique Bouchard, Rémy Gauthier, Jean-François Beaulieu and Pierre H Vachon

    Citation: BMC Cell Biology 2013 14:53

    Published on:

  11. Content type: Research article

    Ischemic preconditioning has been proposed to involve changes in mitochondrial H+ and K+ fluxes, in particular through activation of uncoupling proteins and ATP-sensitive K+ channels (MitoKATP). The objectives of...

    Authors: Saori Morota, Sarah Piel and Magnus J Hansson

    Citation: BMC Cell Biology 2013 14:40

    Published on:

  12. Content type: Methodology article

    Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cel...

    Authors: Archana Vaithilingam, Nicole Y Lai, Ellen Duong, Julie Boucau, Yang Xu, Mariko Shimada, Malini Gandhi and Sylvie Le Gall

    Citation: BMC Cell Biology 2013 14:35

    Published on:

  13. Content type: Research article

    Apoptosis is a form of programmed cell death that is regulated by the Bcl-2 family and caspase family of proteins. The caspase cascade responsible for executing cell death following cytochrome c release is well d...

    Authors: Matthew Brentnall, Luis Rodriguez-Menocal, Rebeka Ladron De Guevara, Enrique Cepero and Lawrence H Boise

    Citation: BMC Cell Biology 2013 14:32

    Published on:

  14. Content type: Research article

    Two pathways are responsible for the majority of regulated protein catabolism in eukaryotic cells: the ubiquitin-proteasome system (UPS) and lysosomal self-degradation through autophagy. Both processes are nec...

    Authors: Péter Lőw, Ágnes Varga, Karolina Pircs, Péter Nagy, Zsuzsanna Szatmári, Miklós Sass and Gábor Juhász

    Citation: BMC Cell Biology 2013 14:29

    Published on:

  15. Content type: Research article

    Cadmium(Cd), a heavy metal, which has a potent harmful effects, is a highly stress-inducible material that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called...

    Authors: Seungwoo Kim, Hyo-Soon Cheon, So-Young Kim, Yong-Sung Juhnn and Young-Youl Kim

    Citation: BMC Cell Biology 2013 14:4

    Published on:

  16. Content type: Research article

    Autophagy is a ubiquitous cellular process responsible for the bulk degradation of cytoplasmic components through the autophagosomal-lysosomal pathway. In skeletal muscle, autophagy has been regarded as a key ...

    Authors: Xiaokun Yu, Junfeng Ma, Feng Lin, Wanke Zhao, Xueqi Fu and Zhizhuang Joe Zhao

    Citation: BMC Cell Biology 2012 13:28

    Published on:

  17. Content type: Research article

    A characteristic feature of frog reproduction is external fertilization accomplished outside the female's body. Mature fertilization-competent frog eggs are arrested at the meiotic metaphase II with high activ...

    Authors: Alexander A Tokmakov, Sho Iguchi, Tetsushi Iwasaki and Yasuo Fukami

    Citation: BMC Cell Biology 2011 12:56

    Published on:

  18. Content type: Research article

    The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity ...

    Authors: Kristin M Slade, Sydney Freggiaro, Kyle A Cottrell, Joshua J Smith and Emily A Wiley

    Citation: BMC Cell Biology 2011 12:40

    Published on:

2018 Journal Metrics

  • Citation Impact

    3.485 - 2-year Impact Factor
    3.227 - 5-year Impact Factor
    0.857 - Source Normalized Impact per Paper (SNIP)
    1.403 - SCImago Journal Rank (SJR)