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Articles

53 result(s) within Volume 22 of BMC Molecular and Cell Biology

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  1. Organic anion transporter 1 (OAT1) is a drug transporter expressed on the basolateral membrane of the proximal tubule cells in kidneys. It plays an essential role in the disposition of numerous clinical therap...

    Authors: Zhou Yu, Chenchang Liu, Jinghui Zhang, Zhengxuan Liang and Guofeng You

    Citation: BMC Molecular and Cell Biology 2021 22:53

    Content type: Research

    Published on:

  2. RhoA is a master regulator of cytoskeletal contractility, while nitric oxide (NO) is a master regulator of relaxation, e.g., vasodilation. There are multiple forms of cross-talk between the RhoA/ROCK pathway a...

    Authors: Akila Surendran, C. Forbes Dewey Jr, Boon Chuan Low and Lisa Tucker-Kellogg

    Citation: BMC Molecular and Cell Biology 2021 22(Suppl 1):47

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 1

  3. Mitochondrial DNA (mtDNA) carrying certain pathogenic mutations or single nucleotide variants (SNVs) enhances the invasion and metastasis of tumor cells, and some of these mutations are homoplasmic in tumor ce...

    Authors: Keizo Takenaga, Nobuko Koshikawa and Hiroki Nagase

    Citation: BMC Molecular and Cell Biology 2021 22:52

    Content type: Research

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  4. Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. A well-described function of apoptosis is the removal of excessive cells during develo...

    Authors: Gabriel Krasovec, Anthi Karaiskou, Éric Quéinnec and Jean-Philippe Chambon

    Citation: BMC Molecular and Cell Biology 2021 22:51

    Content type: Research

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  5. Cryopreservation of human spermatozoa has been identified as an efficient procedure to preserve fertility in men before any cancer therapy or surgical infertility treatment. Despite the benefits of the procedu...

    Authors: Fatemeh Eini, Maryam Azizi kutenaei, Maryam Hosseinzadeh Shirzeyli, Zeinolabedin Sharifian Dastjerdi, Mahmoud Omidi and Marefat Ghaffari Novin

    Citation: BMC Molecular and Cell Biology 2021 22:50

    Content type: Research

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  6. The seriousness and menace of the worldwide weight of ‘Alzheimer’s disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of choli...

    Authors: Olalekan Olanrewaju Bakare, Adewale Oluwaseun Fadaka, Musa Oyebowale Akanbi, Kolajo Adedamola Akinyede, Ashwil Klein and Marshall Keyster

    Citation: BMC Molecular and Cell Biology 2021 22:49

    Content type: Research

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  7. Cisd1 and Cisd2 proteins share very similar structures with an N-terminal membrane-anchoring domain and a C-terminal cytosolic domain containing an iron-cluster binding domain and ending with a C-terminal KKxx...

    Authors: Claudie Bian, Anna Marchetti, Philippe Hammel and Pierre Cosson

    Citation: BMC Molecular and Cell Biology 2021 22:48

    Content type: Research

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  8. MDM2 is an E3 ubiquitin ligase that is able to ubiquitinate p53, targeting it for proteasomal degradation. Its homologue MDMX does not have innate E3 activity, but is able to dimerize with MDM2. Although mouse...

    Authors: Jack D. Sanford, Jing Yang, Jing Han, Laura A. Tollini, Aiwen Jin and Yanping Zhang

    Citation: BMC Molecular and Cell Biology 2021 22:46

    Content type: Research

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  9. The crucial role of the major histocompatibility complex (MHC) for the immune response to infectious diseases is well-known, but no information is available on the 3D nuclear organization of this gene-dense re...

    Authors: Florence Mompart, Alain Kamgoué, Yvette Lahbib-Mansais, David Robelin, Agnès Bonnet, Claire Rogel-Gaillard, Silvia Kocanova and Martine Yerle-Bouissou

    Citation: BMC Molecular and Cell Biology 2021 22:45

    Content type: Research

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  10. Sequence-specific transcription factors (TFs) recognize motifs of related nucleotide sequences at their DNA binding sites. Upon binding at these sites, TFs regulate critical molecular processes such as gene ex...

    Authors: Luis Chumpitaz-Diaz, Md. Abul Hassan Samee and Katherine S. Pollard

    Citation: BMC Molecular and Cell Biology 2021 22:44

    Content type: Research

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  11. The 7SK small nuclear RNA (snRNA) found in most metazoans is a key regulator of P-TEFb which in turn regulates RNA polymerase II elongation. Although its primary sequence varies in protostomes, its secondary s...

    Authors: Duy Nguyen, Nicolas Buisine, Olivier Fayol, Annemieke A. Michels, Olivier Bensaude, David H. Price and Patricia Uguen

    Citation: BMC Molecular and Cell Biology 2021 22:43

    Content type: Research

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  12. Although bacterial infections have been recognized as a possible cause of male infertility, the effect of bacterial infections on sperm quality and sperm DNA fragmentation remains controversial. The current st...

    Authors: Fatemeh Eini, Maryam Azizi Kutenaei, Fayegheh Zareei, Zeinolabedin Sharifian Dastjerdi, Maryam Hosseinzadeh Shirzeyli and Ensieh Salehi

    Citation: BMC Molecular and Cell Biology 2021 22:42

    Content type: Research

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  13. The human SH3 domain Binding Glutamic acid Rich Like 3 (SH3BGRL3) gene is highly conserved in phylogeny and widely expressed in human tissues. However, its function is largely undetermined. The protein was found ...

    Authors: Filippo Di Pisa, Elisa Pesenti, Maria Bono, Andrea N. Mazzarello, Cinzia Bernardi, Michael P. Lisanti, Giovanni Renzone, Andrea Scaloni, Ermanno Ciccone, Franco Fais, Silvia Bruno, Paolo Scartezzini and Fabio Ghiotto

    Citation: BMC Molecular and Cell Biology 2021 22:41

    Content type: Research

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  14. In retinal degenerative disease, progressive and debilitating conditions result in deterioration of retinal cells and visual loss. In human, retina lacks the inherent capacity for regeneration. Therefore, rege...

    Authors: Atefeh Atefi, Pendar Shojaei Kojouri, Fereshteh Karamali, Shiva Irani and Mohammad Hossein Nasr-Esfahani

    Citation: BMC Molecular and Cell Biology 2021 22:40

    Content type: Research article

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  15. Research on cell-in-cell (CIC) phenomena, including entosis, emperipolesis and cannibalism, and their biological implications has increased in recent years. Homotypic and heterotypic engulfment of various targ...

    Authors: Mareike F. Bauer, Michael Hader, Markus Hecht, Maike Büttner-Herold, Rainer Fietkau and Luitpold V. R. Distel

    Citation: BMC Molecular and Cell Biology 2021 22:39

    Content type: Research article

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  16. Proper muscle function is heavily dependent on highly ordered protein complexes. UNC45 is a USC (named since this region is shared by three proteins UNC45/CRO1/She4P) chaperone that is necessary for myosin inc...

    Authors: Abiramy Karunendiran, Christine T. Nguyen, Virginijus Barzda and Bryan A. Stewart

    Citation: BMC Molecular and Cell Biology 2021 22:38

    Content type: Research article

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  17. Organ culture models have been used over the past few decades to study development and disease. The in vitro three-dimensional (3D) culture system of organoids is well known, however, these 3D systems are both...

    Authors: Soran Dakhel, Wayne I. L. Davies, Justin V. Joseph, Tushar Tomar, Silvia Remeseiro and Lena Gunhaga

    Citation: BMC Molecular and Cell Biology 2021 22:37

    Content type: Methodology article

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  18. Climate change and the associated risk for the occurrence of extreme temperature events or permanent changes in ambient temperature are important in the husbandry of farm animals. The aim of our study was to i...

    Authors: Katharina Metzger, Dirk Dannenberger, Armin Tuchscherer, Siriluck Ponsuksili and Claudia Kalbe

    Citation: BMC Molecular and Cell Biology 2021 22:36

    Content type: Research

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  19. Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquino...

    Authors: Aloka B. Bandara, Joshua C. Drake and David A. Brown

    Citation: BMC Molecular and Cell Biology 2021 22:35

    Content type: Research article

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  20. Epidermal growth factor receptor (EGFR) and its signaling pathways play a vital role in pathogenesis of lung cancer. By disturbing EGFR signaling, mutations of EGFR may lead to progression of cancer or the eme...

    Authors: Mengxu Zhu, Debby D. Wang and Hong Yan

    Citation: BMC Molecular and Cell Biology 2021 22:34

    Content type: Research article

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  21. In the present study, fatty acid synthesis is targeted to combat mammary gland carcinoma by activating prolyl hydroxylase-2 with Voacamine alone and in combination with Tamoxifen. It was hypothesized that the ...

    Authors: Lakhveer Singh, Manjari Singh, Shubham Rastogi, Anurag Choudhary, Dinesh Kumar, Ritu Raj, Mohd Nazam Ansari, Abdulaziz S. Saeedan and Gaurav Kaithwas

    Citation: BMC Molecular and Cell Biology 2021 22:33

    Content type: Research

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  22. Endothelial healing after deployment of cardiovascular devices is particularly important in the context of clinical outcome. It is therefore of great interest to develop tools for a precise prediction of endot...

    Authors: Jan Oldenburg, Lisa Maletzki, Anne Strohbach, Paul Bellé, Stefan Siewert, Raila Busch, Stephan B. Felix, Klaus-Peter Schmitz and Michael Stiehm

    Citation: BMC Molecular and Cell Biology 2021 22:32

    Content type: Methodology article

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  24. About 90% of cancer-related deaths are due to metastasis of cancer cells, and angiogenesis is a critical step in this process. sFLT01 is a novel fusion protein and a dual-targeting agent that neutralizes both ...

    Authors: Sepideh Taghizadeh, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiei, Ehsan Ranaei Pirmardan, Ali Kashanian, Fahimeh Zakeri, Hamid Latifi-Navid and Hoda Shams Najafabadi

    Citation: BMC Molecular and Cell Biology 2021 22:30

    Content type: Research

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  25. A large fraction of genes contains upstream ORFs (uORFs) in the 5′ untranslated region (5’UTR). The translation of uORFs can inhibit the translation of the main coding sequence, for example by causing prematur...

    Authors: Simone G. Moro, Cedric Hermans, Jorge Ruiz-Orera and M. Mar Albà

    Citation: BMC Molecular and Cell Biology 2021 22:29

    Content type: Research

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  26. Chronic leg ulcerations are associated with Haemoglobin disorders, Type2 Diabetes Mellitus, and long-term venous insufficiency, where poor perfusion and altered metabolism develop into a chronic inflammation t...

    Authors: Elisa Seria, George Galea, Joseph Borg, Kevin Schembri, Gabriella Grech, Sarah Samut Tagliaferro and Alexander Felice

    Citation: BMC Molecular and Cell Biology 2021 22:28

    Content type: Methodology article

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  27. Dinoflagellates have a generally large number of genes but only a small percentage of these are annotated as transcription factors. Cold shock domain (CSD) containing proteins (CSPs) account for roughly 60% of...

    Authors: Bahareh Zaheri and David Morse

    Citation: BMC Molecular and Cell Biology 2021 22:27

    Content type: Research

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  28. Prostate cancer occurs through multiple steps until advanced metastasis. Signaling pathways studies can result in the identification of targets to interrupt cancer progression. Glypicans are cell surface prote...

    Authors: Gabrielle Ferrante Alves de Moraes, Eduardo Listik, Giselle Zenker Justo, Carolina Meloni Vicente and Leny Toma

    Citation: BMC Molecular and Cell Biology 2021 22:26

    Content type: Research article

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  29. Capsular fibrosis (CF) is the most common long-term complication in implant-based breast augmentation. It is well accepted that the foreign body response (FBR) instigates the development of fibrotic disease. O...

    Authors: Britta Kuehlmann, Isabel Zucal, Clark Andrew Bonham, Lydia-Marie Joubert and Lukas Prantl

    Citation: BMC Molecular and Cell Biology 2021 22:25

    Content type: Methodology article

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  30. Progressive population aging has contributed to the increased global prevalence of diabetes and osteoporosis. Inhibition of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by hyperglyc...

    Authors: Fangzi Gong, Le Gao, Luyao Ma, Guangxin Li and Jianhong Yang

    Citation: BMC Molecular and Cell Biology 2021 22:24

    Content type: Research

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  31. The SARS-CoV-2 virus, the causative agent of COVID-19, consists of an assembly of proteins that determine its infectious and immunological behavior, as well as its response to therapeutics. Major structural bi...

    Authors: Luciano Kagami, Joel Roca-Martínez, Jose Gavaldá-García, Pathmanaban Ramasamy, K. Anton Feenstra and Wim F. Vranken

    Citation: BMC Molecular and Cell Biology 2021 22:23

    Content type: Database

    Published on:

  33. Schwann cells (SCs) play a crucial role in the repair of peripheral nerves. This is due to their ability to proliferate, migrate, and provide trophic support to axon regrowth. During peripheral nerve injury, S...

    Authors: Zhenghui Cheng, Yawen Zhang, Yinchao Tian, Yuhan Chen, Fei Ding, Han Wu, Yuhua Ji and Mi Shen

    Citation: BMC Molecular and Cell Biology 2021 22:21

    Content type: Research article

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  34. Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by bi...

    Authors: Aiyada Aroonsri, Jindaporn Kongsee, Jeremy David Gunawan, Daniel Abidin Aubry and Philip James Shaw

    Citation: BMC Molecular and Cell Biology 2021 22:20

    Content type: Methodology article

    Published on:

  35. The asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional interactions between human bronchial epithelial cells and human bronchi...

    Authors: Milena Paw, Dawid Wnuk, Bogdan Jakieła, Grażyna Bochenek, Krzysztof Sładek, Zbigniew Madeja and Marta Michalik

    Citation: BMC Molecular and Cell Biology 2021 22:19

    Content type: Research article

    Published on:

  36. Reef-building corals regularly experience changes in intra- and extracellular H+ concentrations ([H+]) due to physiological and environmental processes. Stringent control of [H+] is required to maintain the homeo...

    Authors: Laura Capasso, Philippe Ganot, Víctor Planas-Bielsa, Sylvie Tambutté and Didier Zoccola

    Citation: BMC Molecular and Cell Biology 2021 22:18

    Content type: Research article

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  37. Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surfa...

    Authors: Purushottam B. Tiwari, Camelia Bencheqroun, Mario Lemus, Taryn Shaw, Marilyn Kouassi-Brou, Adil Alaoui and Aykut Ãœren

    Citation: BMC Molecular and Cell Biology 2021 22:17

    Content type: Database

    Published on:

  38. Staufen2 (STAU2) is an RNA binding protein involved in the posttranscriptional regulation of gene expression. In neurons, STAU2 is required to maintain the balance between differentiation and proliferation of ...

    Authors: Lionel Condé, Yulemi Gonzalez Quesada, Florence Bonnet-Magnaval, Rémy Beaujois and Luc DesGroseillers

    Citation: BMC Molecular and Cell Biology 2021 22:16

    Content type: Research article

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  39. Previously, we revealed sexually dimorphic mRNA expression and responsiveness to maternal dietary supplementation with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in placentas from a defined INFAT stud...

    Authors: Eva-Maria Sedlmeier, Dorothy M. Meyer, Lynne Stecher, Manuela Sailer, Hannelore Daniel, Hans Hauner and Bernhard L. Bader

    Citation: BMC Molecular and Cell Biology 2021 22:15

    Content type: Research article

    Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: J. Gautron, L. Stapane, N. Le Roy, Y. Nys, A. B. Rodriguez-Navarro and M. T. Hincke

    Citation: BMC Molecular and Cell Biology 2021 22:14

    Content type: Correction

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    The original article was published in BMC Molecular and Cell Biology 2021 22:11

  41. Human induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have emerged as potentially viable therapies for spinal cord injuries and...

    Authors: Emilia Solomon, Katie Davis-Anderson, Blake Hovde, Sofiya Micheva-Viteva, Jennifer Foster Harris, Scott Twary and Rashi Iyer

    Citation: BMC Molecular and Cell Biology 2021 22:13

    Content type: Research article

    Published on:

  42. Enterocytes exert an absorptive and protective function in the intestine, and they encounter many different challenging factors such as feed, bacteria, and parasites. An intestinal epithelial in vitro model ca...

    Authors: Federico Ghiselli, Barbara Rossi, Martina Felici, Maria Parigi, Giovanni Tosi, Laura Fiorentini, Paola Massi, Andrea Piva and Ester Grilli

    Citation: BMC Molecular and Cell Biology 2021 22:12

    Content type: Methodology article

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  43. The avian eggshell is a natural protective envelope that relies on the phenomenon of biomineralization for its formation. The shell is made of calcium carbonate in the form of calcite, which contains hundreds ...

    Authors: J. Gautron, L. Stapane, N. Le Roy, Y. Nys, A. B. Rodriguez-Navarro and M. T. Hincke

    Citation: BMC Molecular and Cell Biology 2021 22:11

    Content type: Review

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    The Correction to this article has been published in BMC Molecular and Cell Biology 2021 22:14

  44. Musashi1 (MSI1) is an oncogenic protein with a crucial role in the proliferation and characteristics of the epithelial cells in breast cancer. The change in expression of MSI1 has a role in solid tumor progressio...

    Authors: Mahboobeh Forouzanfar, Liana Lachinani, Kianoush Dormiani, Mohammad Hossein Nasr-Esfahani and Kamran Ghaedi

    Citation: BMC Molecular and Cell Biology 2021 22:10

    Content type: Research article

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  46. Warts, hypogammaglobulinemia, recurrent bacterial infections and myelokathexis (WHIM) syndrome is a primary immunodeficiency disease (PID) usually caused by autosomal dominant mutations in the chemokine receptor

    Authors: Liqing Wang, Qiuhong Xiong, Ping Li, Guangxin Chen, Nayab Tariq and Changxin Wu

    Citation: BMC Molecular and Cell Biology 2021 22:8

    Content type: Research article

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  47. One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genom...

    Authors: Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He and Dong Yang

    Citation: BMC Molecular and Cell Biology 2021 22:7

    Content type: Research article

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  48. Circular RNAs (circRNAs) are endogenous non-coding RNAs, which are associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529...

    Authors: Xing Zhang, Hongwei Yang, Yingdong Jia, Zhengwen Xu, Liuping Zhang, Meng Sun and Jing Fu

    Citation: BMC Molecular and Cell Biology 2021 22:6

    Content type: Research article

    Published on:

  49. Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these cells have strict controls over their metabolic processes, including...

    Authors: Elisa A. Bonnin, Eugenio F. Fornasiero, Felix Lange, Christoph W. Turck and Silvio O. Rizzoli

    Citation: BMC Molecular and Cell Biology 2021 22:5

    Content type: Research article

    Published on:

  50. Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

    Authors: Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu, Chao Zhang, Huai-Ming Sang, Yan-Yan Liu, Guo-Xin Zhang, Jian-Xia Jiang and Shun-Fu Xu

    Citation: BMC Molecular and Cell Biology 2021 22:4

    Content type: Research article

    Published on:

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