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  1. Basic functions of the eukaryotic nucleus, like transcription and replication, are regulated in a hierarchic fashion. It is assumed that epigenetic factors influence the efficiency and precision of these proce...

    Authors: Isa M Stehle, Jan Postberg, Sina Rupprecht, Thomas Cremer, Dean A Jackson and Hans J Lipps

    Citation: BMC Cell Biology 2007 8:33

    Content type: Research article

    Published on:

  2. Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease and Parkinson's disease. Proteins containing long, homopolymeric stretches of glutamine are especially pro...

    Authors: Rebecca A Howard, Pratima Sharma, Connie Hajjar, Kim A Caldwell, Guy A Caldwell, Rusla du Breuil, Rhonda Moore and Lynn Boyd

    Citation: BMC Cell Biology 2007 8:32

    Content type: Research article

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  3. 14-3-3 proteins have been implicated in many signalling mechanisms due to their interaction with Ser/Thr phosphorylated target proteins. They are evolutionarily well conserved in eukaryotic organisms from sing...

    Authors: Barbara Pauly, Margherita Lasi, Carol MacKintosh, Nick Morrice, Axel Imhof, Jörg Regula, Stephen Rudd, Charles N David and Angelika Böttger

    Citation: BMC Cell Biology 2007 8:31

    Content type: Research article

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  4. Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk for the development of a range of disorde...

    Authors: Matthew W Lawless, Arun K Mankan, Mary White, Michael J O'Dwyer and Suzanne Norris

    Citation: BMC Cell Biology 2007 8:30

    Content type: Research article

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  5. Spinal muscular atrophy is caused by reduced levels of the survival of motor neurons (SMN) protein. SMN is found in large complexes with Sm proteins and at least eight other proteins, including seven "gemins"....

    Authors: Le thi Hao, Heidi R Fuller, Le Thanh Lam, Thanh T Le, Arthur HM Burghes and Glenn E Morris

    Citation: BMC Cell Biology 2007 8:28

    Content type: Research article

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  6. Applications in biomedical science and life science produce large data sets using increasingly powerful imaging devices and computer simulations. It is becoming increasingly difficult for scientists to explore...

    Authors: Oliver G Staadt, Vijay Natarajan, Gunther H Weber, David F Wiley and Bernd Hamann

    Citation: BMC Cell Biology 2007 8(Suppl 1):S10

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  7. The processing of images acquired through microscopy is a challenging task due to the large size of datasets (several gigabytes) and the fast turnaround time required. If the throughput of the image processing...

    Authors: A Ravishankar Rao, Guillermo A Cecchi and Marcelo Magnasco

    Citation: BMC Cell Biology 2007 8(Suppl 1):S9

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  8. We present an analysis of the utility of multispectral versus standard RGB imagery for routine H&E stained histopathology images, in particular for pixel-level classification of nuclei. Our multispectral image...

    Authors: Laura E Boucheron, Zhiqiang Bi, Neal R Harvey, BS Manjunath and David L Rimm

    Citation: BMC Cell Biology 2007 8(Suppl 1):S8

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  9. Staining the m RNA of a gene via in situ hybridization (ISH) during the development of a D. melanogaster embryo delivers the detailed spatio-temporal pattern of expression of the gene. Many biological problems su...

    Authors: Hanchuan Peng, Fuhui Long, Jie Zhou, Garmay Leung, Michael B Eisen and Eugene W Myers

    Citation: BMC Cell Biology 2007 8(Suppl 1):S7

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  10. Biological experiments increasingly yield data representing large ensembles of interacting variables, making the application of advanced analytical tools a forbidding task. We present a method to extract netwo...

    Authors: Guillermo A Cecchi, A Ravishankar Rao, Maria V Centeno, Marwan Baliki, A Vania Apkarian and Dante R Chialvo

    Citation: BMC Cell Biology 2007 8(Suppl 1):S5

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  11. The dynamic growing and shortening behaviors of microtubules are central to the fundamental roles played by microtubules in essentially all eukaryotic cells. Traditionally, microtubule behavior is quantified b...

    Authors: Alphan Altınok, Erkan Kiris, Austin J Peck, Stuart C Feinstein, Leslie Wilson, BS Manjunath and Kenneth Rose

    Citation: BMC Cell Biology 2007 8(Suppl 1):S4

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  12. The distribution of chromatin-associated proteins plays a key role in directing nuclear function. Previously, we developed an image-based method to quantify the nuclear distributions of proteins and showed tha...

    Authors: Fuhui Long, Hanchuan Peng, Damir Sudar, Sophie A Lelièvre and David W Knowles

    Citation: BMC Cell Biology 2007 8(Suppl 1):S3

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  13. With the improvements in biosensors and high-throughput image acquisition technologies, life science laboratories are able to perform an increasing number of experiments that involve the generation of a large ...

    Authors: Raphaël Marée, Pierre Geurts and Louis Wehenkel

    Citation: BMC Cell Biology 2007 8(Suppl 1):S2

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  14. The 2006 International Workshop on Multiscale Biological Imaging, Data Mining and Informatics was held at Santa Barbara, on Sept 7–8, 2006. Based on the presentations at the workshop, we selected and compiled ...

    Authors: Manfred Auer, Hanchuan Peng and Ambuj Singh

    Citation: BMC Cell Biology 2007 8(Suppl 1):S1

    Content type: Introduction

    Published on:

    This article is part of a Supplement: Volume 8 Supplement 1

  15. In response to DNA damage or structural alterations of chromatin, histone H2AX may be phosphorylated on Ser 139 by phosphoinositide 3-kinase related protein kinases (PIKKs) such as ataxia telangiectasia mutated (...

    Authors: Toshiki Tanaka, Xuan Huang, Ellen Jorgensen, Diana Gietl, Frank Traganos, Zbigniew Darzynkiewicz and Anthony P Albino

    Citation: BMC Cell Biology 2007 8:26

    Content type: Research article

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  16. Endocytosis is a key regulator of growth factor signaling pathways. Recent studies showed that the localization to endosomes of intracellular mediators of growth factor signaling may be required for their func...

    Authors: Ramya Rajagopal, Shunsuke Ishii and David C Beebe

    Citation: BMC Cell Biology 2007 8:25

    Content type: Research article

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  17. Rho subfamily GTPases are implicated in a large number of actin-related processes. They shuttle from an inactive GDP-bound form to an active GTP-bound form. This reaction is catalysed by Guanine nucleotide exc...

    Authors: Subhanjan Mondal, Dhamodharan Neelamegan, Francisco Rivero and Angelika A Noegel

    Citation: BMC Cell Biology 2007 8:23

    Content type: Research article

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  18. Neuronal ceroid lipofuscinoses (NCLs) are collectively the most common type of recessively inherited childhood encephalopathies. The most severe form of NCL, infantile neuronal ceroid lipofuscinosis (INCL), is...

    Authors: Annina Lyly, Carina von Schantz, Tarja Salonen, Outi Kopra, Jani Saarela, Matti Jauhiainen, Aija Kyttälä and Anu Jalanko

    Citation: BMC Cell Biology 2007 8:22

    Content type: Research article

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  19. The pig, Sus scrofa domestica includes both the miniature and commercial domestic breed. These animals have influenced the human life and economies and have been studied throughout history. Although the miniature...

    Authors: Ho-Yeon Oh, Xun Jin, Jong-Geun Kim, Myung-Joo Oh, Xumin Pian, Jun-Mo Kim, Moon-Seok Yoon, Chae-Ik Son, Young Sik Lee, Ki-Chang Hong, Hyunggee Kim, Yun-Jaie Choi and Kwang Youn Whang

    Citation: BMC Cell Biology 2007 8:20

    Content type: Research article

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  20. Aggresomes are pericentrosomal accumulations of misfolded proteins, chaperones and proteasomes. Their positioning near the centrosome, like that of other organelles, requires active, microtubule-dependent tran...

    Authors: Györgyi Szebenyi, W Christian Wigley, Branden Hall, Aaron Didier, Michelle Yu, Philip Thomas and Helmut Krämer

    Citation: BMC Cell Biology 2007 8:19

    Content type: Research article

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  21. Potential therapeutic use of mesenchymal stem cells (MSCs) is likely to require large-scale in vitro expansion of the cells before transplantation. MSCs from adipose tissue can be cultured extensively until se...

    Authors: Agate Noer, Andrew C Boquest and Philippe Collas

    Citation: BMC Cell Biology 2007 8:18

    Content type: Research article

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  22. Sulfur mustard (SM) is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of SM gas causes airway inflammation and injury. In recent years, there has b...

    Authors: Xiugong Gao, Radharaman Ray, Yan Xiao, Peter E Barker and Prabhati Ray

    Citation: BMC Cell Biology 2007 8:17

    Content type: Research article

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  23. Bcl-2 family proteins are key regulators of mitochondrial integrity and comprise both pro- and anti-apoptotic proteins. Bax a pro-apoptotic member localizes as monomers in the cytosol of healthy cells and accu...

    Authors: Neha Parikh, Caroline Koshy, Vaigundan Dhayabaran, Lakshmi R Perumalsamy, R Sowdhamini and Apurva Sarin

    Citation: BMC Cell Biology 2007 8:16

    Content type: Research article

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  24. Phosphatidylinositol 4,5-bisphosphate (PIP2) is required for successful completion of cytokinesis. In addition, both PIP2 and phosphoinositide-specific phospholipase C (PLC) have been localized to the cleavage fu...

    Authors: Raymond Wong, Lacramioara Fabian, Arthur Forer and Julie A Brill

    Citation: BMC Cell Biology 2007 8:15

    Content type: Research article

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  25. It has been recognized that dermal fibroblasts and matrix metalloproteases (MMP) play crucial roles in wound healing process in skin. Thrombin was found to stimulate IL-8 release from human dermal fibroblasts ...

    Authors: Li Wang, Jianmin Luo and Shaoheng He

    Citation: BMC Cell Biology 2007 8:14

    Content type: Research article

    Published on:

  26. The NCOA7 gene product is an estrogen receptor associated protein that is highly similar to the human OXR1 gene product, which functions in oxidation resistance. OXR genes are conserved among all sequenced euk...

    Authors: Mathieu Durand, Adrianne Kolpak, Timothy Farrell, Nathan A Elliott, Wenlin Shao, Myles Brown and Michael R Volkert

    Citation: BMC Cell Biology 2007 8:13

    Content type: Research article

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  27. Norrin is a potent Wnt pathway ligand. Aberrant activation of this signaling pathway can result in colon tumors but the role of norrin-based signaling in the genesis of colon cancer, and its relationship to ac...

    Authors: Kestutis Planutis, Marina Planutiene, Mary Pat Moyer, Anthony V Nguyen, Cherlyn A Pérez and Randall F Holcombe

    Citation: BMC Cell Biology 2007 8:12

    Content type: Research article

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  28. When exposed to oxidative conditions, cells suffer not only biochemical alterations, but also morphologic changes. Oxidative stress is a condition induced by some pro-oxidant compounds, such as by tert-butylhy...

    Authors: Vilma A Sardão, Paulo J Oliveira, Jon Holy, Catarina R Oliveira and Kendall B Wallace

    Citation: BMC Cell Biology 2007 8:11

    Content type: Research article

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  29. The lymphatic system complements the blood circulatory system in absorption and transport of nutrients, and in the maintenance of homeostasis. Angiopoietins 1 and 2 (Ang1 and Ang2) are regulators of both angio...

    Authors: Vicky PKH Nguyen, Stephen H Chen, Jason Trinh, Harold Kim, Brenda L Coomber and Daniel J Dumont

    Citation: BMC Cell Biology 2007 8:10

    Content type: Research article

    Published on:

  30. Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 ac...

    Authors: Øystein L Holla, Jamie Cameron, Knut Erik Berge, Trine Ranheim and Trond P Leren

    Citation: BMC Cell Biology 2007 8:9

    Content type: Research article

    Published on:

  31. CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fractio...

    Authors: Barbara Ulmasov, Jonathan Bruno, Philip G Woost and John C Edwards

    Citation: BMC Cell Biology 2007 8:8

    Content type: Research article

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  32. Bcl-2 homology domain (BH) 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to the mitochondrial cell death pathways. The BH3-only protein Bid can be activated in respo...

    Authors: Hans-Georg König, Markus Rehm, Daniel Gudorf, Stan Krajewski, Atan Gross, Manus W Ward and Jochen HM Prehn

    Citation: BMC Cell Biology 2007 8:7

    Content type: Research article

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  33. Recombinant adenovirus vectors and transfection agents comprising cationic lipids are widely used as gene delivery vehicles for functional expression in cultured cells. Consequently, these tools are utilized t...

    Authors: Monica Andersson, Malin Warolén, Joakim Nilsson, Martin Selander, Catharina Sterky, Katrin Bergdahl, Christina Sörving, Stephen R James and Magnus Doverskog

    Citation: BMC Cell Biology 2007 8:6

    Content type: Methodology article

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  34. The main role of the chromosomal passenger complex is to ensure that Aurora B kinase is properly localized and activated before and during mitosis. Borealin, a member of the chromosomal passenger complex, show...

    Authors: Harpreet Kaur, Andrew C Stiff, Dipali A Date and William R Taylor

    Citation: BMC Cell Biology 2007 8:5

    Content type: Research article

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  35. The four highly homologous human EHD proteins (EHD1-4) form a distinct subfamily of the Eps15 homology domain-containing protein family and are thought to regulate endocytic recycling. Certain members of this ...

    Authors: Manju George, GuoGuang Ying, Mark A Rainey, Aharon Solomon, Pankit T Parikh, Qingshen Gao, Vimla Band and Hamid Band

    Citation: BMC Cell Biology 2007 8:3

    Content type: Research article

    Published on:

  36. Connective tissue growth factor (CTGF) is a potent profibrotic factor, which is implicated in fibroblast proliferation, angiogenesis and extracellular matrix (ECM) synthesis. It is a downstream mediator of som...

    Authors: Xiaojing Liu, Fengming Luo, Kejian Pan, Wenchao Wu and Huaiqing Chen

    Citation: BMC Cell Biology 2007 8:1

    Content type: Research article

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  37. Aspartyl (asparaginyl)-β-hydroxylase (AAH) hydroxylates Asp and Asn residues within EGF-like domains of Notch and Jagged, which mediate cell motility and differentiation. This study examines the expression, re...

    Authors: Stephanie A Lahousse, Jade J Carter, Xaolai J Xu, Jack R Wands and Suzanne M de la Monte

    Citation: BMC Cell Biology 2006 7:41

    Content type: Research article

    Published on:

  38. 2-Chloroethyl ethyl sulphide (CEES) is a sulphur vesicating agent and an analogue of the chemical warfare agent 2,2'-dichlorodiethyl sulphide, or sulphur mustard gas (HD). Both CEES and HD are alkylating agent...

    Authors: Min Qui, Victor M Paromov, Hongsong Yang, Milton Smith and William L Stone

    Citation: BMC Cell Biology 2006 7:39

    Content type: Research article

    Published on:

  39. The nuclear lamina is a protein meshwork lining the inner nuclear membrane, which contains a polymer of nuclear lamins associated with transmembrane proteins of the inner nuclear membrane. The lamina is involv...

    Authors: I-Hsiung Brandon Chen, Michael Huber, Tinglu Guan, Anja Bubeck and Larry Gerace

    Citation: BMC Cell Biology 2006 7:38

    Content type: Research article

    Published on:

  40. Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation ...

    Authors: Petra Lynen Jansen, Raphael Rosch, Melanie Rezvani, Peter R Mertens, Karsten Junge, Marc Jansen and Uwe Klinge

    Citation: BMC Cell Biology 2006 7:36

    Content type: Research article

    Published on:

2018 Journal Metrics

  • Citation Impact

    3.485 - 2-year Impact Factor
    3.227 - 5-year Impact Factor
    0.857 - Source Normalized Impact per Paper (SNIP)
    1.403 - SCImago Journal Rank (SJR)

    Usage 
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