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  1. The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many cellular developmental processes. The widespread occurrence...

    Authors: Joanna S Brooke, Jeong-Heon Cha and Leon Eidels
    Citation: BMC Cell Biology 2002 3:2
  2. Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations in the X-linked MID1 gene, which encodes a microtubule-bi...

    Authors: Kieran M Short, Blair Hopwood, Zou Yi and Timothy C Cox
    Citation: BMC Cell Biology 2002 3:1
  3. Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single phospholipase C gene (PLC); deletion of the gene has no effect o...

    Authors: Peter Van Dijken and Peter JM Van Haastert
    Citation: BMC Cell Biology 2001 2:25
  4. Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts. In this study, we examined the reason for the reduced surface e...

    Authors: Kazuhide Takahashi
    Citation: BMC Cell Biology 2001 2:23
  5. Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic gonadotropi...

    Authors: Jimmy D Neill, L Wayne Duck, Jeffrey C Sellers, Lois C Musgrove and John H Kehrl
    Citation: BMC Cell Biology 2001 2:21
  6. During apoptosis, Ca2+-dependent events participate in the regulation of intracellular and morphological changes including phosphatidylserine exposure in the exoplasmic leaflet of the cell plasma membrane. The oc...

    Authors: M Carmen Martínez and Jean-Marie Freyssinet
    Citation: BMC Cell Biology 2001 2:20
  7. The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogen...

    Authors: Kwesi O Mercurius and Alex O Morla
    Citation: BMC Cell Biology 2001 2:18
  8. Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin sup...

    Authors: Tamir Gonen, Angus C Grey, Marc D Jacobs, Paul J Donaldson and Joerg Kistler
    Citation: BMC Cell Biology 2001 2:17
  9. SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examin...

    Authors: Amitabha Basu, Lorraine H Kligman, Stefan J Samulewicz and Chin C Howe
    Citation: BMC Cell Biology 2001 2:15
  10. The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate t...

    Authors: Antonio D McCarthy, Susana B Etcheverry, Liliana Bruzzone, Gabriela Lettieri, Daniel A Barrio and Ana M Cortizo
    Citation: BMC Cell Biology 2001 2:16
  11. Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to inhibit gap junctional intercellular ...

    Authors: Lance E Wyatt, Chi Y Chung, Brian Carlsen, Akiko Iida-Klein, George H Rudkin, Kenji Ishida, Dean T Yamaguchi and Timothy A Miller
    Citation: BMC Cell Biology 2001 2:14
  12. Filopodia, retraction fibers and microvilli, are fragile microextensions of the plasma membrane that are easily damaged by mechanical force during specimen preparation for microscopy. To preserve these structu...

    Authors: Fumihiko Nakamura
    Citation: BMC Cell Biology 2001 2:10
  13. Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of accumulating compatible osmolytes as it has been described for a w...

    Authors: Tanja Pintsch, Michel Satre, Gérard Klein, Jean-Baptiste Martin and Stephan C Schuster
    Citation: BMC Cell Biology 2001 2:9
  14. Dimerization is an important regulatory mechanism of single membrane-spanning receptors. For instance, activation of receptor protein-tyrosine kinases (RPTKs) involves dimerization. Structural, functional and ...

    Authors: Leon GJ Tertoolen, Christophe Blanchetot, Guoqiang Jiang, John Overvoorde, Theodorus WJ Gadella Jr, Tony Hunter and Jeroen den Hertog
    Citation: BMC Cell Biology 2001 2:8
  15. Ethylene is a widely distributed alkene product which is formed enzymatically (e.g., in plants) or by photochemical reactions (e.g., in the upper oceanic layers from dissolved organic carbon). This gaseous com...

    Authors: Sanja Perovic, Jürgen Seack, Vera Gamulin, Werner EG Müller and Heinz C Schröder
    Citation: BMC Cell Biology 2001 2:7
  16. In most cells glucocorticoid receptors (GR) reside predominately in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription...

    Authors: David A Dean, Gudrun Urban, Ileana V Aragon, Mark Swingle, Beth Miller, Sandro Rusconi, Manuel Bueno, Nicholas M Dean and Richard E Honkanen
    Citation: BMC Cell Biology 2001 2:6
  17. Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the anti...

    Authors: Nataliya S Kavok, Oksana A Krasilnikova and Nataliya A Babenko
    Citation: BMC Cell Biology 2001 2:5
  18. A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, ...

    Authors: Nicole Garreau de Loubresse, Françoise Ruiz, Janine Beisson and Catherine Klotz
    Citation: BMC Cell Biology 2001 2:4
  19. Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents such as 17β-...

    Authors: Helen E Gruber, Igor J Puzanov, Michael Bennett, Vinay Kumar and Brian Gordon
    Citation: BMC Cell Biology 2001 2:3
  20. Aside from muscle, brain is also a major expression site for dystrophin, the protein whose abnormal expression is responsible for Duchenne muscular dystrophy. Cognitive impairments are frequently associated wi...

    Authors: Kevin Culligan, Louise Glover, Paul Dowling and Kay Ohlendieck
    Citation: BMC Cell Biology 2001 2:2
  21. Atherosclerosis and coronary heart disease (CHD) are significant contributors to morbidity and mortality in developed countries. A noted exception is the low mortality of CHD in France, particularly the southw...

    Authors: Jed L Bruder, Tze-chen Hsieh, Kenneth M Lerea, Susan C Olson and Joseph M Wu
    Citation: BMC Cell Biology 2001 2:1
  22. The hepatic stellate cell is the primary cell type responsible for the excessive formation and deposition of connective tissue elements during the development of hepatic fibrosis in chronically injured liver. ...

    Authors: Ralf Weiskirchen, Jens Kneifel, Sabine Weiskirchen, Eddy van de Leur, Dagmar Kunz and Axel M Gressner
    Citation: BMC Cell Biology 2000 1:4
  23. In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon cha...

    Authors: Ismael Mingarro, IngMarie Nilsson, Paul Whitley and Gunnar von Heijne
    Citation: BMC Cell Biology 2000 1:3
  24. The cell surface undergoes continuous change during cell movement. This is characterized by transient protrusion and partial or complete retraction of microspikes, filopodia, and lamellipodia. This requires a ...

    Authors: Pninit Litman, Manuel Ricardo Amieva and Heinz Furthmayr
    Citation: BMC Cell Biology 2000 1:1

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