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  1. The transport of intra-cellular particles by microtubules is a major biological function. Under appropriate in vitro conditions, microtubule preparations behave as a 'complex' system and show 'emergent' phenomena...

    Authors: Nicolas Glade, Jacques Demongeot and James Tabony
    Citation: BMC Cell Biology 2004 5:23
  2. The peptidyl-prolyl isomerase Pin1 recently revealed itself as a new player in the regulation of protein function by phosphorylation. Pin1 isomerizes the peptide bond of specific phosphorylated serine or threo...

    Authors: Alexandra L Albert, Sébastien B Lavoie and Michel Vincent
    Citation: BMC Cell Biology 2004 5:22
  3. Cytochalasin B does not directly activate the oxygen-radical-producing NADPH oxidase activity of neutrophils but transfers desensitized G-protein coupled receptors (GPCR) into an active signaling state by unco...

    Authors: Johan Bylund, Sara Pellmé, Huamei Fu, Ulf-Henrik Mellqvist, Kristoffer Hellstrand, Anna Karlsson and Claes Dahlgren
    Citation: BMC Cell Biology 2004 5:21
  4. The Transforming Growth Factor-β (TGF-β) regulates myriad cellular events by signaling through members of the Smad family signal transducers. As a key signal transducer of TGF-β, Smad3 exhibits the property of...

    Authors: Claire Nourry, Lola Maksumova, Mona Pang, Xiaohong Liu and Tongwen Wang
    Citation: BMC Cell Biology 2004 5:20
  5. Gelsolin, an actin capping protein of osteoclast podosomes, has a unique function in regulating assembly and disassembly of the podosome actin filament. Previously, we have reported that osteopontin (OPN) bind...

    Authors: Rajat S Biswas, De Anna Baker, Keith A Hruska and Meenakshi A Chellaiah
    Citation: BMC Cell Biology 2004 5:19
  6. Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeleta...

    Authors: Yael Fridmann-Sirkis, Symeon Siniossoglou and Hugh RB Pelham
    Citation: BMC Cell Biology 2004 5:18
  7. Projectin is a giant modular protein of Drosophila muscles and a key component of the elastic connecting filaments (C-filaments), which are involved in stretch activation in insect Indirect Flight Muscles. It is ...

    Authors: Agnes Ayme-Southgate, Christophe Bounaix, Theresa E Riebe and Richard Southgate
    Citation: BMC Cell Biology 2004 5:17
  8. The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively...

    Authors: Zhihong Chen, Yinlin Ge and Jing X Kang
    Citation: BMC Cell Biology 2004 5:15
  9. It is known that "second-hand" cigarette smoke leads to abnormal tissue repair and remodelling but the cellular mechanisms involved in these adverse effects are not well understood. Fibroblasts play a major ro...

    Authors: Lina S Wong, Harry Miguel Green, Jo Ellen Feugate, Madhav Yadav, Eugene A Nothnagel and Manuela Martins-Green
    Citation: BMC Cell Biology 2004 5:13
  10. The autosomal dominant form of Emery-Dreifuss muscular dystrophy (AD-EDMD) is caused by mutations in the gene encoding for the lamins A and C (LMNA). Lamins are intermediate filament proteins which form the nu...

    Authors: Beate Reichart, Ruth Klafke, Christine Dreger, Eleonora Krüger, Isabell Motsch, Andrea Ewald, Jochen Schäfer, Heinz Reichmann, Clemens R Müller and Marie-Christine Dabauvalle
    Citation: BMC Cell Biology 2004 5:12
  11. α1-antitrypsin (AAT) is one of the major serine proteinase inhibitors controlling proteinases in many biological pathways. There is increasing evidence that AAT is able to exert other than antiproteolytic effe...

    Authors: Ruta Aldonyte, Lennart Jansson and Sabina Janciauskiene
    Citation: BMC Cell Biology 2004 5:11
  12. Opitz G/BBB syndrome is a genetic disorder characterized by developmental midline abnormalities, such as hypertelorism, cleft palate, and hypospadias. The gene responsible for the X-linked form of this disease, M...

    Authors: Caterina Berti, Bianca Fontanella, Rosa Ferrentino and Germana Meroni
    Citation: BMC Cell Biology 2004 5:9
  13. "Protein-trap" is a method that allows epitope-tagging of endogenous proteins. This method allows for the identification of endogenously expressed proteins that exhibit specific localization of interest. This ...

    Authors: Olga O Sineshchekova, Toshimitsu Kawate, Oleksandr V Vdovychenko and Thomas N Sato
    Citation: BMC Cell Biology 2004 5:8
  14. Transfection agents comprised of cationic lipid preparations are widely used to transfect cell lines in culture with specific recombinant complementary DNA molecules. We have found that cells in culture are of...

    Authors: Camilla Pramfalk, Johanna Lanner, Monica Andersson, Eva Danielsson, Christina Kaiser, Ing-Marie Renström, Malin Warolén and Stephen R James
    Citation: BMC Cell Biology 2004 5:7
  15. Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial ce...

    Authors: Gerasimos Filippatos, Edmund Ang, Claudia Gidea, Erhan Dincer, Rongqi Wang and Bruce D Uhal
    Citation: BMC Cell Biology 2004 5:6
  16. Phenylephrine (PHE), an α1 adrenergic receptor agonist, increases phospholipase D (PLD) activity, independent of classical and novel protein kinase C (PKC) isoforms, in rat-1 fibroblasts expressing α1A adrenergic...

    Authors: Jean-Hugues Parmentier, Gautam K Gandhi, Monique T Wiggins, Abdelwahab E Saeed, Sylvain G Bourgoin and Kafait U Malik
    Citation: BMC Cell Biology 2004 5:4
  17. Transforming growth factor-βs (TGF-βs), bone morphogenetic proteins (BMPs) and activins are important regulators of developmental cell growth and differentiation. Signaling by these factors is mediated chiefly...

    Authors: Nieves Ibarrola, Irina Kratchmarova, Daisuke Nakajima, William P Schiemann, Aristidis Moustakas, Akhilesh Pandey and Matthias Mann
    Citation: BMC Cell Biology 2004 5:2
  18. Upon serial passaging of mouse skeletal muscle cells, a small number of cells will spontaneously develop the ability to proliferate indefinitely while retaining the ability to differentiate into multinucleate ...

    Authors: Jonathan A Nowak, Jonathan Malowitz, Mahasweta Girgenrath, Christine A Kostek, Amanda J Kravetz, Janice A Dominov and Jeffrey Boone Miller
    Citation: BMC Cell Biology 2004 5:1
  19. In Arabidopsis thaliana, the gene Tousled encodes a protein kinase of unknown function, but mutations in the gene lead to flowering and leaf morphology defects. We have recently cloned a mammalian Tousled-L ike K

    Authors: Gulshan Sunavala-Dossabhoy, Yuan Li, Briana Williams and Arrigo De Benedetti
    Citation: BMC Cell Biology 2003 4:16
  20. Apoptosis occurs frequently for blastocysts cultured in vitro, where conditions are suboptimal to those found in the natural environment. Insulin-like growth factor-1 (IGF-1) plays an important role in preventing...

    Authors: Ta-Chin Lin, Jui-Mei Yen, Kun-Bing Gong, Teng-Tsao Hsu and Lih-Ren Chen
    Citation: BMC Cell Biology 2003 4:14
  21. Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanis...

    Authors: Hai-Sheng Li, Kuntala Shome, Raúl Rojas, Megan A Rizzo, Chandrasekaran Vasudevan, Eric Fluharty, Lorraine C Santy, James E Casanova and Guillermo Romero
    Citation: BMC Molecular and Cell Biology 2003 4:13
  22. Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threo...

    Authors: Eishi Funakoshi, Takamitsu Hori, Tokuko Haraguchi, Yasushi Hiraoka, Jun Kudoh, Nobuyoshi Shimizu and Fumiaki Ito
    Citation: BMC Cell Biology 2003 4:12
  23. The progression of normal cells through the cell cycle is meticulously regulated by checkpoints guaranteeing the exact replication of the genome during S-phase and its equal division at mitosis. A prerequisite...

    Authors: Ulrike Kronenwett, Juan Castro, Uwe J Roblick, Kaoru Fujioka, Carin Östring, Farinaz Faridmoghaddam, Nongnit Laytragoon-Lewin, Bernhard Tribukait and Gert Auer
    Citation: BMC Cell Biology 2003 4:8
  24. The cytotoxicity and the rejoining of DNA double-strand breaks induced by γ-rays, H2O2 and neocarzinostatin, were investigated in normal and PARP-1 knockout mouse 3T3 fibroblasts to determine the role of poly(ADP...

    Authors: Georges Noël, Nicole Giocanti, Marie Fernet, Frédérique Mégnin-Chanet and Vincent Favaudon
    Citation: BMC Cell Biology 2003 4:7
  25. Protein Ser/Thr phosphatase 5 (PP5) and its Saccharomyces cerevisiae homolog protein phosphatase T1 (Ppt1p) each contain an N-terminal domain consisting of several tetratricopeptide repeats (TPRs) and a C-termina...

    Authors: Jee-Yeong Jeong, Jeremiah Johns, Christopher Sinclair, Jung-Min Park and Sandra Rossie
    Citation: BMC Cell Biology 2003 4:3
  26. Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.

    Authors: Darren G Woodside, David K Wooten, T Kent Teague, Yuko J Miyamoto, Eva G Caudell, Taturo Udagawa, Bernard F Andruss and Bradley W McIntyre
    Citation: BMC Cell Biology 2003 4:2
  27. Constitutive photomorphogenic 1 (COP1) has been defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation. Although ...

    Authors: Chunling Yi, Haiyang Wang, Ning Wei and Xing Wang Deng
    Citation: BMC Cell Biology 2002 3:30
  28. Mutations in P0, the major protein of the myelin sheath in peripheral nerves, cause the inherited peripheral neuropathies Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome (DSS) and congeni...

    Authors: Arif B Ekici, Sevinc Oezbey, Christina Fuchs, Eva Nelis, Christine Van Broeckhoven, Melitta Schachner and Bernd Rautenstrauss
    Citation: BMC Cell Biology 2002 3:29
  29. Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel ...

    Authors: Luca Jovine, Jong Park and Paul M Wassarman
    Citation: BMC Cell Biology 2002 3:28
  30. The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-def...

    Authors: Christopher J Armit, Shirley O'Dea, Alan R Clarke and David J Harrison
    Citation: BMC Cell Biology 2002 3:27
  31. Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-lin...

    Authors: José S Ramalho, Ross Anders, Gesine B Jaissle, Mathias W Seeliger, Clare Huxley and Miguel C Seabra
    Citation: BMC Cell Biology 2002 3:26
  32. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family...

    Authors: William A Maltese, Gwendolyn Soule, William Gunning, Edward Calomeni and Brandy Alexander
    Citation: BMC Cell Biology 2002 3:25
  33. Down syndrome is the most frequent genetic disorder in humans. Rare cases involving partial trisomy of chromosome 21 allowed a small chromosomal region common to all carriers, called Down Syndrome Critical Reg...

    Authors: Sandra Cristina Pfister, Gláucia Maria Machado-Santelli, Sang Won Han and Flávio Henrique-Silva
    Citation: BMC Cell Biology 2002 3:24
  34. Epstein-Barr virus (EBV) infects resting B-lymphocytes and transforms them into immortal proliferating lymphoblastoid cell lines (LCLs) in vitro. The transformed immunoblasts may grow up as immunoblastic lymphoma...

    Authors: Elena Kashuba, Vladimir Kashuba, Tatjana Sandalova, George Klein and Laszlo Szekely
    Citation: BMC Cell Biology 2002 3:23

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