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  1. The progression of normal cells through the cell cycle is meticulously regulated by checkpoints guaranteeing the exact replication of the genome during S-phase and its equal division at mitosis. A prerequisite...

    Authors: Ulrike Kronenwett, Juan Castro, Uwe J Roblick, Kaoru Fujioka, Carin Östring, Farinaz Faridmoghaddam, Nongnit Laytragoon-Lewin, Bernhard Tribukait and Gert Auer
    Citation: BMC Cell Biology 2003 4:8
  2. The cytotoxicity and the rejoining of DNA double-strand breaks induced by γ-rays, H2O2 and neocarzinostatin, were investigated in normal and PARP-1 knockout mouse 3T3 fibroblasts to determine the role of poly(ADP...

    Authors: Georges Noël, Nicole Giocanti, Marie Fernet, Frédérique Mégnin-Chanet and Vincent Favaudon
    Citation: BMC Cell Biology 2003 4:7
  3. Protein Ser/Thr phosphatase 5 (PP5) and its Saccharomyces cerevisiae homolog protein phosphatase T1 (Ppt1p) each contain an N-terminal domain consisting of several tetratricopeptide repeats (TPRs) and a C-termina...

    Authors: Jee-Yeong Jeong, Jeremiah Johns, Christopher Sinclair, Jung-Min Park and Sandra Rossie
    Citation: BMC Cell Biology 2003 4:3
  4. Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton.

    Authors: Darren G Woodside, David K Wooten, T Kent Teague, Yuko J Miyamoto, Eva G Caudell, Taturo Udagawa, Bernard F Andruss and Bradley W McIntyre
    Citation: BMC Cell Biology 2003 4:2
  5. Constitutive photomorphogenic 1 (COP1) has been defined as a central regulator of photomorphogenic development in plants, which targets key transcription factors for proteasome-dependent degradation. Although ...

    Authors: Chunling Yi, Haiyang Wang, Ning Wei and Xing Wang Deng
    Citation: BMC Cell Biology 2002 3:30
  6. Mutations in P0, the major protein of the myelin sheath in peripheral nerves, cause the inherited peripheral neuropathies Charcot-Marie-Tooth disease type 1B (CMT1B), Dejerine-Sottas syndrome (DSS) and congeni...

    Authors: Arif B Ekici, Sevinc Oezbey, Christina Fuchs, Eva Nelis, Christine Van Broeckhoven, Melitta Schachner and Bernd Rautenstrauss
    Citation: BMC Cell Biology 2002 3:29
  7. Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator of gel ...

    Authors: Luca Jovine, Jong Park and Paul M Wassarman
    Citation: BMC Cell Biology 2002 3:28
  8. The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-def...

    Authors: Christopher J Armit, Shirley O'Dea, Alan R Clarke and David J Harrison
    Citation: BMC Cell Biology 2002 3:27
  9. Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-lin...

    Authors: José S Ramalho, Ross Anders, Gesine B Jaissle, Mathias W Seeliger, Clare Huxley and Miguel C Seabra
    Citation: BMC Cell Biology 2002 3:26
  10. Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes distinguish this protein from other members of the Rab family...

    Authors: William A Maltese, Gwendolyn Soule, William Gunning, Edward Calomeni and Brandy Alexander
    Citation: BMC Cell Biology 2002 3:25
  11. Down syndrome is the most frequent genetic disorder in humans. Rare cases involving partial trisomy of chromosome 21 allowed a small chromosomal region common to all carriers, called Down Syndrome Critical Reg...

    Authors: Sandra Cristina Pfister, Gláucia Maria Machado-Santelli, Sang Won Han and Flávio Henrique-Silva
    Citation: BMC Cell Biology 2002 3:24
  12. Epstein-Barr virus (EBV) infects resting B-lymphocytes and transforms them into immortal proliferating lymphoblastoid cell lines (LCLs) in vitro. The transformed immunoblasts may grow up as immunoblastic lymphoma...

    Authors: Elena Kashuba, Vladimir Kashuba, Tatjana Sandalova, George Klein and Laszlo Szekely
    Citation: BMC Cell Biology 2002 3:23
  13. The P-glycoprotein (P-gp), an ATP binding cassette transmembrane transporter, is expressed by astrocytes in the adult brain, and is positively modulated during astrogliosis. In a search for factors involved in...

    Authors: Christelle Monville, Christiane Fages, Anne-Marie Feyens, Véronique d'Hondt, Catherine Guillet, Ann Vernallis, Hugues Gascan and Marc Peschanski
    Citation: BMC Cell Biology 2002 3:20
  14. Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated...

    Authors: Wenchuan Liang, Lucila S Licate, Hans M Warrick, James A Spudich and Thomas T Egelhoff
    Citation: BMC Cell Biology 2002 3:19
  15. Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differ...

    Authors: Daniel SW Tan, Alexandra Cook and Shern L Chew
    Citation: BMC Cell Biology 2002 3:17
  16. The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding trans...

    Authors: Yin Lin, Jennifer Martin, Cornelia Gruendler, Jennifer Farley, Xianwang Meng, Bi-Yu Li, Robert Lechleider, Carla Huff, Richard H Kim, William Grasser, Vishwas Paralkar and Tongwen Wang
    Citation: BMC Cell Biology 2002 3:15
  17. Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically altered cells due to the failure of cellular suicide progr...

    Authors: Véronique Le Mellay, Jakob Troppmair, Roland Benz and Ulf R Rapp
    Citation: BMC Cell Biology 2002 3:14
  18. During wound repair, fibroblasts orchestrate replacement of the provisional matrix formed during clotting with tenascin, cellular fibronectin and collagen III. These, in turn, are critical for migration of end...

    Authors: Jo Ellen Feugate, Lina Wong, Qi-Jing Li and Manuela Martins-Green
    Citation: BMC Cell Biology 2002 3:13
  19. Elevated plasma counts of endothelial microparticles (MP) have been demonstrated in various diseases with a vascular injury component. We used flow cytometry to study the MP-release from cultured human umbilic...

    Authors: Jan Šimák, Karel Holada and Jaroslav G Vostal
    Citation: BMC Cell Biology 2002 3:11
  20. Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis. It has been demonstrated that hepat...

    Authors: Hong Shen, Manna Zhang, Gerald Y Minuk and Yuewen Gong
    Citation: BMC Cell Biology 2002 3:9
  21. Liver sinusoidal endothelial cells (LSECs) react to different anti-actin agents by increasing their number of fenestrae. A new structure related to fenestrae formation could be observed when LSECs were treated...

    Authors: Filip Braet, Ilan Spector, Nava Shochet, Phillip Crews, Tatsuo Higa, Eline Menu, Ronald de Zanger and Eddie Wisse
    Citation: BMC Cell Biology 2002 3:7
  22. A number of transcription factors coordinate differentiation by simultaneously regulating gene expression and cell proliferation. CCAAT/enhancer binding protein alpha (C/EBPα) is a basic/leucine zipper transcr...

    Authors: Weiqun Liu, John F Enwright III, William Hyun, Richard N Day and Fred Schaufele
    Citation: BMC Cell Biology 2002 3:6
  23. Previous studies have shown that several agents that stimulate heptahelical G-protein coupled receptors activate the extracellular signal regulated kinases ERK1 (p44mapk) and ERK2 (p42mapk) in hepatocytes. The mo...

    Authors: Øyvind Melien, Laila S Nilssen, Olav F Dajani, Kristin Larsen Sand, Jens-Gustav Iversen, Dagny L Sandnes and Thoralf Christoffersen
    Citation: BMC Cell Biology 2002 3:5
  24. The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many cellular developmental processes. The widespread occurrence...

    Authors: Joanna S Brooke, Jeong-Heon Cha and Leon Eidels
    Citation: BMC Cell Biology 2002 3:2
  25. Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations in the X-linked MID1 gene, which encodes a microtubule-bi...

    Authors: Kieran M Short, Blair Hopwood, Zou Yi and Timothy C Cox
    Citation: BMC Cell Biology 2002 3:1
  26. Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single phospholipase C gene (PLC); deletion of the gene has no effect o...

    Authors: Peter Van Dijken and Peter JM Van Haastert
    Citation: BMC Cell Biology 2001 2:25
  27. Structural requirements for the β1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts. In this study, we examined the reason for the reduced surface e...

    Authors: Kazuhide Takahashi
    Citation: BMC Cell Biology 2001 2:23
  28. Luteinizing hormone secreted by the anterior pituitary gland regulates gonadal function. Luteinizing hormone secretion is regulated both by alterations in gonadotrope responsiveness to hypothalamic gonadotropi...

    Authors: Jimmy D Neill, L Wayne Duck, Jeffrey C Sellers, Lois C Musgrove and John H Kehrl
    Citation: BMC Cell Biology 2001 2:21
  29. During apoptosis, Ca2+-dependent events participate in the regulation of intracellular and morphological changes including phosphatidylserine exposure in the exoplasmic leaflet of the cell plasma membrane. The oc...

    Authors: M Carmen Martínez and Jean-Marie Freyssinet
    Citation: BMC Cell Biology 2001 2:20
  30. The first type III repeat of fibronectin is known to be involved in fibronectin matrix assembly, and recombinant proteins from this type III repeat can inhibit cell proliferation, tumor metastasis and angiogen...

    Authors: Kwesi O Mercurius and Alex O Morla
    Citation: BMC Cell Biology 2001 2:18
  31. Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin sup...

    Authors: Tamir Gonen, Angus C Grey, Marc D Jacobs, Paul J Donaldson and Joerg Kistler
    Citation: BMC Cell Biology 2001 2:17
  32. SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examin...

    Authors: Amitabha Basu, Lorraine H Kligman, Stefan J Samulewicz and Chin C Howe
    Citation: BMC Cell Biology 2001 2:15
  33. The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate t...

    Authors: Antonio D McCarthy, Susana B Etcheverry, Liliana Bruzzone, Gabriela Lettieri, Daniel A Barrio and Ana M Cortizo
    Citation: BMC Cell Biology 2001 2:16
  34. Bone morphogenetic proteins (BMPs) and transforming growth factor-βs (TGF-βs) are important regulators of bone repair and regeneration. BMP-2 and TGF-β1 have been shown to inhibit gap junctional intercellular ...

    Authors: Lance E Wyatt, Chi Y Chung, Brian Carlsen, Akiko Iida-Klein, George H Rudkin, Kenji Ishida, Dean T Yamaguchi and Timothy A Miller
    Citation: BMC Cell Biology 2001 2:14

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