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  1. One striking feature of the large KRAB domain-containing zinc finger protein (KZFP) family is its rapid evolution, leading to hundreds of member genes with various origination time in a certain mammalian genom...

    Authors: Pan Shen, Aishi Xu, Yushan Hou, Huqiang Wang, Chao Gao, Fuchu He and Dong Yang
    Citation: BMC Molecular and Cell Biology 2021 22:7
    Content type: Research article Published on:

  2. Circular RNAs (circRNAs) are endogenous non-coding RNAs, which are associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529...

    Authors: Xing Zhang, Hongwei Yang, Yingdong Jia, Zhengwen Xu, Liuping Zhang, Meng Sun and Jing Fu
    Citation: BMC Molecular and Cell Biology 2021 22:6
    Content type: Research article Published on:

  3. Most of the cells of the mammalian retina are terminally differentiated, and do not regenerate once fully developed. This implies that these cells have strict controls over their metabolic processes, including...

    Authors: Elisa A. Bonnin, Eugenio F. Fornasiero, Felix Lange, Christoph W. Turck and Silvio O. Rizzoli
    Citation: BMC Molecular and Cell Biology 2021 22:5
    Content type: Research article Published on:

  4. Pathogenesis of Helicobacter Pylori (HP) vacuolating toxin A (vacA) depends on polymorphic diversity within the signal (s), middle (m), intermediate (i), deletion (d) and c-regions. These regions show distinct al...

    Authors: Djaleel Muhammad Soyfoo, Yussriya Hanaa Doomah, Dong Xu, Chao Zhang, Huai-Ming Sang, Yan-Yan Liu, Guo-Xin Zhang, Jian-Xia Jiang and Shun-Fu Xu
    Citation: BMC Molecular and Cell Biology 2021 22:4
    Content type: Research article Published on:

  5. Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue p...

    Authors: Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada and Masanori Osawa
    Citation: BMC Molecular and Cell Biology 2021 22:3
    Content type: Research article Published on:

  6. Breast cancer 2, early onset (BRCA2) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in BRCA2 and d...

    Authors: Yasunaga Yoshikawa, Hajime Kozuma, Masami Morimatsu, Kaori Sugawara and Koichi Orino
    Citation: BMC Molecular and Cell Biology 2021 22:2
    Content type: Research article Published on:

  7. Culturing primary epithelial cells has a major advantage over tumor-derived or immortalized cell lines as long as their functional phenotype and genetic makeup are mainly maintained. The swine model has shown ...

    Authors: Henry Bautista-Amorocho, Jorge Alexander Silva-Sayago, Diego A. Goyeneche-Patino, Tania Liseth Pérez-Cala, Fabio Macías-Gómez, Juan Carlos Arango-Viana and Alonso Martínez
    Citation: BMC Molecular and Cell Biology 2021 22:1
    Content type: Methodology article Published on:

  8. In rice, the cortex and outer tissues play a key role in submergence tolerance. The cortex differentiates into aerenchyma, which are air-containing cavities that allow the flow of oxygen from shoots to roots, ...

    Authors: Thibault Mounier, Sergi Navarro-Sanz, Charlotte Bureau, Lefeuvre Antoine, Fabrice Varoquaux, Franz Durandet and Christophe Périn
    Citation: BMC Molecular and Cell Biology 2020 21:92
    Content type: Methodology article Published on:

  9. The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse.

    Authors: Weiya Zhang, Juan Ni, Jie Zhang, Lu Zhang, Huanhuan Zhou, Changzhi Zhao, Mengjin Zhu, Haiyan Wang, Jianlin Han, Xinyun Li and Shuhong Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:91
    Content type: Research article Published on:

  10. The zoonotic worm parasite Fasciola hepatica secretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymoge...

    Authors: Izanara C. Pritsch, Irina G. Tikhonova, Heather L. Jewhurst, Orla Drysdale, Krystyna Cwiklinski, Marcelo B. Molento, John P. Dalton and Carolina De M. Verissimo
    Citation: BMC Molecular and Cell Biology 2020 21:90
    Content type: Research article Published on:

  11. Type A influenza viruses are contagious and even life-threatening if left untreated. So far, no broadly protective vaccine is available due to rapid antigenic changes and emergence of new subtypes of influenza...

    Authors: Davod Jafari, Sara Malih, Mohammad Mahmoudi Gomari, Marzieh Safari, Rasool Jafari and Mohammad Morad Farajollahi
    Citation: BMC Molecular and Cell Biology 2020 21:89
    Content type: Research article Published on:

  12. Popeye domain-containing proteins 1 and 2 (POPDC1 and POPDC2) are transmembrane proteins involved in cyclic AMP-mediated signalling processes and are required for normal cardiac pacemaking and conduction. In o...

    Authors: Ian Holt, Heidi R. Fuller, Roland F. R. Schindler, Sally L. Shirran, Thomas Brand and Glenn E. Morris
    Citation: BMC Molecular and Cell Biology 2020 21:88
    Content type: Research article Published on:

  13. Caenorhabditis elegans is an excellent model organism for biological research, but its contributions to biochemical elucidation of eukaryotic transcription mechanisms have been limited. One of the biggest obstacl...

    Authors: Phillip Wibisono, Yiyong Liu and Jingru Sun
    Citation: BMC Molecular and Cell Biology 2020 21:87
    Content type: Methodology article Published on:

  14. Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The gen...

    Authors: R. Christian McDonald, Matthew J. Schott, Temitope A. Idowu and Peter J. Lyons
    Citation: BMC Molecular and Cell Biology 2020 21:86
    Content type: Research article Published on:

  15. Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs; liver resident macrophages) form the body’s most effective scavenger cell system for the removal of harmful blood-borne substances, ranging fr...

    Authors: Sabin Bhandari, Ruomei Li, Jaione Simón-Santamaría, Peter McCourt, Steinar Daae Johansen, Bård Smedsrød, Inigo Martinez-Zubiaurre and Karen Kristine Sørensen
    Citation: BMC Molecular and Cell Biology 2020 21:85
    Content type: Research article Published on:

  16. Maintenance of centrosome number in cells is essential for accurate distribution of chromosomes at mitosis and is dependent on both proper centrosome duplication during interphase and their accurate distributi...

    Authors: Alan-Michael Bresch, Nadiya Yerich, Rong Wang and Ann O. Sperry
    Citation: BMC Molecular and Cell Biology 2020 21:84
    Content type: Research article Published on:

  17. The effects of diverse stresses ultimately alter the structures and functions of proteins. As molecular chaperones, heat shock proteins (HSPs) are a group of highly conserved proteins that help in the refoldin...

    Authors: Xin Zhang, Yuting Li, Yulong Sun, Mingxing Guo, Jianjun Feng, Yilei Wang and Ziping Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:83
    Content type: Research article Published on:

  18. Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A fe...

    Authors: Olalekan Olanrewaju Bakare, Marshall Keyster and Ashley Pretorius
    Citation: BMC Molecular and Cell Biology 2020 21:82
    Content type: Research article Published on:

  19. Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood. The aim of this study is to characterize Tau s...

    Authors: André Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs and Marc H. Mercken
    Citation: BMC Molecular and Cell Biology 2020 21:81
    Content type: Research article Published on:

  20. Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fib...

    Authors: Qiang Chen, Jiuyang Jiao, Youyuan Wang, Zhihui Mai, Jing Ren, Sijie He, Xiaolan Li and Zheng Chen
    Citation: BMC Molecular and Cell Biology 2020 21:80
    Content type: Research article Published on:

  21. Non-professional phagocytosis is usually triggered by stimuli such as necrotic cell death. In tumor therapy, the tumors often disappear slowly and only long time after the end of therapy. Here, tumor therapy i...

    Authors: Dorian Gottwald, Florian Putz, Nora Hohmann, Maike Büttner-Herold, Markus Hecht, Rainer Fietkau and Luitpold Distel
    Citation: BMC Molecular and Cell Biology 2020 21:79
    Content type: Research article Published on:

  23. Local Chinese local pig breeds have thinner muscle fiber and higher intramuscular-fat (IMF) content. But its regulation mechanism has not been discussed in-depth. Studies indicated that long non coding RNAs (l...

    Authors: Jing Wang, Ming-yue Chen, Jun-feng Chen, Qiao-ling Ren, Jia-qing Zhang, Hai Cao, Bao-song Xing and Chuan-ying Pan
    Citation: BMC Molecular and Cell Biology 2020 21:77
    Content type: Research article Published on:

  24. MreB is a bacterial ortholog of actin and forms mobile filaments underneath the cell membrane, perpendicular to the long axis of the cell, which play a crucial role for cell shape maintenance. We wished to vis...

    Authors: Simon Dersch, Christian Reimold, Joshua Stoll, Hannes Breddermann, Thomas Heimerl, Hervé Joel Defeu Soufo and Peter L. Graumann
    Citation: BMC Molecular and Cell Biology 2020 21:76
    Content type: Research article Published on:

  25. Many cell permeabilisation methods to mediate internalisation of various molecules to mammalian or bacterial cells have been developed. However, no size-specific permeability assay suitable for both cell types...

    Authors: Yensi Flores Bueso, Sidney Walker, Jennifer Quinn and Mark Tangney
    Citation: BMC Molecular and Cell Biology 2020 21:75
    Content type: Methodology article Published on:

  26. The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a dir...

    Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado and José L. Pablos
    Citation: BMC Molecular and Cell Biology 2020 21:74
    Content type: Research article Published on:

  27. Persistence is a natural phenomenon whereby a subset of a population of isogenic bacteria either grow slow or become dormant conferring them with the ability to withstand various stresses including antibiotics...

    Authors: Cyrus Alexander, Ankeeta Guru, Pinkilata Pradhan, Sunanda Mallick, Nimai Charan Mahanandia, Bharat Bhusan Subudhi and Tushar Kant Beuria
    Citation: BMC Molecular and Cell Biology 2020 21:73
    Content type: Research article Published on:

  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng
    Citation: BMC Molecular and Cell Biology 2020 21:72
    Content type: Correction Published on:

    The original article was published in BMC Cell Biology 2016 17:21

  29. The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular...

    Authors: Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix and Lucio Comai
    Citation: BMC Molecular and Cell Biology 2020 21:71
    Content type: Research article Published on:

  30. Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein ...

    Authors: Shamsul Morshed, Most Naoshia Tasnin and Takashi Ushimaru
    Citation: BMC Molecular and Cell Biology 2020 21:70
    Content type: Research article Published on:

  31. Long non-coding RNAs (lncRNAs) are novel regulatory molecules in breast cancer development. LncRNA LUCAT1 is a potential tumor promoter in human cancers. In this study, we aimed to explore the role of LUCAT1 i...

    Authors: Yun Liu, Teng Cheng, Yaying Du, Xiaopeng Hu and Wenfei Xia
    Citation: BMC Molecular and Cell Biology 2020 21:69
    Content type: Research article Published on:

  32. MCF-7 breast cancer cell line is undoubtedly amongst the most extensively studied patient-derived research models, providing pivotal results that have over the decades translated to constantly improving patien...

    Authors: Nityanand Jain, Dina Nitisa, Valdis Pirsko and Inese Cakstina
    Citation: BMC Molecular and Cell Biology 2020 21:68
    Content type: Research article Published on:

  33. G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological ro...

    Authors: Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh and Perumal Vivekanandan
    Citation: BMC Molecular and Cell Biology 2020 21:67
    Content type: Research article Published on:

  34. The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic endocrine disruptors. In particular, exposure of the developing testis to exogenous estrogen ...

    Authors: Melanie K. Stewart, Deidre M. Mattiske and Andrew J. Pask
    Citation: BMC Molecular and Cell Biology 2020 21:66
    Content type: Research article Published on:

  35. The human Obg-like ATPase 1 (OLA1) protein has been reported to play an important role in cancer cell proliferation. The molecular mechanism underlying OLA1 regulated oral metastasis is still unknown. We inves...

    Authors: Jianzhou Liu, Qing Yang, Kevin Chen Xiao, Thomas Dobleman, Shen Hu and Gary Guishan Xiao
    Citation: BMC Molecular and Cell Biology 2020 21:65
    Content type: Research article Published on:

  36. It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivota...

    Authors: Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider and Volker Huck
    Citation: BMC Molecular and Cell Biology 2020 21:64
    Content type: Research article Published on:

  37. Eye pigmentation genes have been utilized as visible markers for constructing genetic control prototypes in several insect vectors of human disease. Here, orthologs of two ommochrome pathway genes, kynurenine 3-h...

    Authors: Xuejiao Xu, Tim Harvey-Samuel, Jie Yang, Luke Alphey and Minsheng You
    Citation: BMC Molecular and Cell Biology 2020 21:63
    Content type: Research article Published on:

  38. Microbial Interaction Networks (MINs) provide important information for understanding bacterial communities. MINs can be inferred by examining microbial abundance profiles. Abundance profiles are often interpr...

    Authors: Rajith Vidanaarachchi, Marnie Shaw, Sen-Lin Tang and Saman Halgamuge
    Citation: BMC Molecular and Cell Biology 2020 21(Suppl 1):34
    Content type: Research Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  39. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Oluwatosin Oluwadare, Max Highsmith, Douglass Turner, Erez Lieberman Aiden and Jianlin Cheng
    Citation: BMC Molecular and Cell Biology 2020 21:62
    Content type: Correction Published on:

    The original article was published in BMC Molecular and Cell Biology 2020 21:60

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sandeep Singh, Varsheish Raina, Pavithra Lakshminarsimhan Chavali, Taronish Dubash, Sreenath Kadreppa, Pradeep Parab and Samit Chattopadhyay
    Citation: BMC Molecular and Cell Biology 2020 21:61
    Content type: Correction Published on:

    The original article was published in BMC Molecular Biology 2012 13:28

  41. Advances in the study of chromosome conformation capture technologies, such as Hi-C technique - capable of capturing chromosomal interactions in a genome-wide scale - have led to the development of three-dimen...

    Authors: Oluwatosin Oluwadare, Max Highsmith, Douglass Turner, Erez Lieberman Aiden and Jianlin Cheng
    Citation: BMC Molecular and Cell Biology 2020 21:60
    Content type: Database Published on:

    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:62

  42. We have previously reported 18S and 25S ribosomal RNA molecules in Candida albicans resistant to processive 5′ → 3′ exonuclease, appearing as cells approached stationary growth phase. Initial analysis pointed to ...

    Authors: Jacob Fleischmann, Miguel A. Rocha, Peter V. Hauser, Bhavani S. Gowda and Mary Grace D. Pilapil
    Citation: BMC Molecular and Cell Biology 2020 21:59
    Content type: Research article Published on:

  43. Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer’s disease (AD). Recent evidence has suggested that ...

    Authors: Allaura S. Cone, Stephanie N. Hurwitz, Gloria S. Lee, Xuegang Yuan, Yi Zhou, Yan Li and David G. Meckes Jr
    Citation: BMC Molecular and Cell Biology 2020 21:58
    Content type: Research article Published on:

  44. Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy. This study aimed to investigate the e...

    Authors: Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun and Ke Yao
    Citation: BMC Molecular and Cell Biology 2020 21:57
    Content type: Research article Published on:

  45. Type 2 diabetes mellitus (T2DM) is a worldwide disease that have an impact on individuals of all ages causing micro and macro vascular impairments due to hyperglycemic internal environment. For ultimate treatm...

    Authors: Syed Aun Muhammad, Hiba Ashfaq, Sidra Zafar, Fahad Munir, Muhammad Babar Jamshed, Jake Chen and Qiyu Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:56
    Content type: Research article Published on:

  46. The details of the folding mechanisms have not yet been fully understood for many proteins, and it is believed that the information on the folding mechanism of a protein is encoded in its amino acid sequence. ...

    Authors: Risako Kimura, Panyavut Aumpuchin, Shoya Hamaue, Takumi Shimomura and Takeshi Kikuchi
    Citation: BMC Molecular and Cell Biology 2020 21:28
    Content type: Research article Published on:

  47. The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and p...

    Authors: Sara Martire, Jennifer Nguyen, Aishwarya Sundaresan and Laura A. Banaszynski
    Citation: BMC Molecular and Cell Biology 2020 21:55
    Content type: Research article Published on:

  48. Trichomonas vaginalis, the causative agent of a prevalent urogenital infection in humans, is an evolutionarily divergent protozoan. Protein-coding genes in T. vaginalis are largely controlled by two core promoter...

    Authors: Shuqi E. Wang, Anna E. S. Brooks, Anthony M. Poole and Augusto Simoes-Barbosa
    Citation: BMC Molecular and Cell Biology 2020 21:54
    Content type: Research article Published on:

  49. Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mech...

    Authors: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li and Jiao Jiao Li
    Citation: BMC Molecular and Cell Biology 2020 21:53
    Content type: Research article Published on:

  50. The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised o...

    Authors: Jose Liñares-Blanco, Cristian R. Munteanu, Alejandro Pazos and Carlos Fernandez-Lozano
    Citation: BMC Molecular and Cell Biology 2020 21:52
    Content type: Research article Published on:
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