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  1. The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a dir...

    Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado and José L. Pablos
    Citation: BMC Molecular and Cell Biology 2020 21:74
  2. Persistence is a natural phenomenon whereby a subset of a population of isogenic bacteria either grow slow or become dormant conferring them with the ability to withstand various stresses including antibiotics...

    Authors: Cyrus Alexander, Ankeeta Guru, Pinkilata Pradhan, Sunanda Mallick, Nimai Charan Mahanandia, Bharat Bhusan Subudhi and Tushar Kant Beuria
    Citation: BMC Molecular and Cell Biology 2020 21:73
  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ye Zhao, Xi Qiao, Lihua Wang, Tian Kui Tan, Hong Zhao, Yun Zhang, Jianlin Zhang, Padmashree Rao, Qi Cao, Yiping Wang, Ya Wang, Yuan Min Wang, Vincent W. S. Lee, Stephen I. Alexander, David C. H. Harris and Guoping Zheng
    Citation: BMC Molecular and Cell Biology 2020 21:72

    The original article was published in BMC Cell Biology 2016 17:21

  4. The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular...

    Authors: Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix and Lucio Comai
    Citation: BMC Molecular and Cell Biology 2020 21:71
  5. Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein ...

    Authors: Shamsul Morshed, Most Naoshia Tasnin and Takashi Ushimaru
    Citation: BMC Molecular and Cell Biology 2020 21:70
  6. Long non-coding RNAs (lncRNAs) are novel regulatory molecules in breast cancer development. LncRNA LUCAT1 is a potential tumor promoter in human cancers. In this study, we aimed to explore the role of LUCAT1 i...

    Authors: Yun Liu, Teng Cheng, Yaying Du, Xiaopeng Hu and Wenfei Xia
    Citation: BMC Molecular and Cell Biology 2020 21:69
  7. MCF-7 breast cancer cell line is undoubtedly amongst the most extensively studied patient-derived research models, providing pivotal results that have over the decades translated to constantly improving patien...

    Authors: Nityanand Jain, Dina Nitisa, Valdis Pirsko and Inese Cakstina
    Citation: BMC Molecular and Cell Biology 2020 21:68
  8. G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological ro...

    Authors: Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh and Perumal Vivekanandan
    Citation: BMC Molecular and Cell Biology 2020 21:67
  9. The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic endocrine disruptors. In particular, exposure of the developing testis to exogenous estrogen ...

    Authors: Melanie K. Stewart, Deidre M. Mattiske and Andrew J. Pask
    Citation: BMC Molecular and Cell Biology 2020 21:66
  10. The human Obg-like ATPase 1 (OLA1) protein has been reported to play an important role in cancer cell proliferation. The molecular mechanism underlying OLA1 regulated oral metastasis is still unknown. We inves...

    Authors: Jianzhou Liu, Qing Yang, Kevin Chen Xiao, Thomas Dobleman, Shen Hu and Gary Guishan Xiao
    Citation: BMC Molecular and Cell Biology 2020 21:65
  11. It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivota...

    Authors: Matthias F. Schneider, Mohammad A. Fallah, Christian Mess, Tobias Obser, Reinhard Schneppenheim, Alfredo Alexander-Katz, Stefan W. Schneider and Volker Huck
    Citation: BMC Molecular and Cell Biology 2020 21:64
  12. Eye pigmentation genes have been utilized as visible markers for constructing genetic control prototypes in several insect vectors of human disease. Here, orthologs of two ommochrome pathway genes, kynurenine 3-h...

    Authors: Xuejiao Xu, Tim Harvey-Samuel, Jie Yang, Luke Alphey and Minsheng You
    Citation: BMC Molecular and Cell Biology 2020 21:63
  13. Microbial Interaction Networks (MINs) provide important information for understanding bacterial communities. MINs can be inferred by examining microbial abundance profiles. Abundance profiles are often interpr...

    Authors: Rajith Vidanaarachchi, Marnie Shaw, Sen-Lin Tang and Saman Halgamuge
    Citation: BMC Molecular and Cell Biology 2020 21(Suppl 1):34

    This article is part of a Supplement: Volume 21 Supplement 1

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Oluwatosin Oluwadare, Max Highsmith, Douglass Turner, Erez Lieberman Aiden and Jianlin Cheng
    Citation: BMC Molecular and Cell Biology 2020 21:62

    The original article was published in BMC Molecular and Cell Biology 2020 21:60

  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sandeep Singh, Varsheish Raina, Pavithra Lakshminarsimhan Chavali, Taronish Dubash, Sreenath Kadreppa, Pradeep Parab and Samit Chattopadhyay
    Citation: BMC Molecular and Cell Biology 2020 21:61

    The original article was published in BMC Molecular Biology 2012 13:28

  16. Advances in the study of chromosome conformation capture technologies, such as Hi-C technique - capable of capturing chromosomal interactions in a genome-wide scale - have led to the development of three-dimen...

    Authors: Oluwatosin Oluwadare, Max Highsmith, Douglass Turner, Erez Lieberman Aiden and Jianlin Cheng
    Citation: BMC Molecular and Cell Biology 2020 21:60

    The Correction to this article has been published in BMC Molecular and Cell Biology 2020 21:62

  17. We have previously reported 18S and 25S ribosomal RNA molecules in Candida albicans resistant to processive 5′ → 3′ exonuclease, appearing as cells approached stationary growth phase. Initial analysis pointed to ...

    Authors: Jacob Fleischmann, Miguel A. Rocha, Peter V. Hauser, Bhavani S. Gowda and Mary Grace D. Pilapil
    Citation: BMC Molecular and Cell Biology 2020 21:59
  18. Endosomal trafficking and amyloidogenic cleavage of amyloid precursor protein (APP) is believed to play a role in the neurodegeneration observed in Alzheimer’s disease (AD). Recent evidence has suggested that ...

    Authors: Allaura S. Cone, Stephanie N. Hurwitz, Gloria S. Lee, Xuegang Yuan, Yi Zhou, Yan Li and David G. Meckes Jr
    Citation: BMC Molecular and Cell Biology 2020 21:58
  19. Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy. This study aimed to investigate the e...

    Authors: Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun and Ke Yao
    Citation: BMC Molecular and Cell Biology 2020 21:57
  20. Type 2 diabetes mellitus (T2DM) is a worldwide disease that have an impact on individuals of all ages causing micro and macro vascular impairments due to hyperglycemic internal environment. For ultimate treatm...

    Authors: Syed Aun Muhammad, Hiba Ashfaq, Sidra Zafar, Fahad Munir, Muhammad Babar Jamshed, Jake Chen and Qiyu Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:56
  21. The details of the folding mechanisms have not yet been fully understood for many proteins, and it is believed that the information on the folding mechanism of a protein is encoded in its amino acid sequence. ...

    Authors: Risako Kimura, Panyavut Aumpuchin, Shoya Hamaue, Takumi Shimomura and Takeshi Kikuchi
    Citation: BMC Molecular and Cell Biology 2020 21:28
  22. The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and p...

    Authors: Sara Martire, Jennifer Nguyen, Aishwarya Sundaresan and Laura A. Banaszynski
    Citation: BMC Molecular and Cell Biology 2020 21:55
  23. Trichomonas vaginalis, the causative agent of a prevalent urogenital infection in humans, is an evolutionarily divergent protozoan. Protein-coding genes in T. vaginalis are largely controlled by two core promoter...

    Authors: Shuqi E. Wang, Anna E. S. Brooks, Anthony M. Poole and Augusto Simoes-Barbosa
    Citation: BMC Molecular and Cell Biology 2020 21:54
  24. Long noncoding RNAs (lncRNAs) are recently found to be critical regulators of the epigenome. However, our knowledge of their role in osteoarthritis (OA) development is limited. This study investigates the mech...

    Authors: Yang Yang, Dan Xing, Yawei Wang, Haobo Jia, Bing Li and Jiao Jiao Li
    Citation: BMC Molecular and Cell Biology 2020 21:53
  25. The main challenge in cancer research is the identification of different omic variables that present a prognostic value and personalised diagnosis for each tumour. The fact that the diagnosis is personalised o...

    Authors: Jose Liñares-Blanco, Cristian R. Munteanu, Alejandro Pazos and Carlos Fernandez-Lozano
    Citation: BMC Molecular and Cell Biology 2020 21:52
  26. Β-glucosidases are key enzymes used in second-generation biofuel production. They act in the last step of the lignocellulose saccharification, converting cellobiose in glucose. However, most of the β-glucosida...

    Authors: Diego Mariano, Naiara Pantuza, Lucianna H. Santos, Rafael E. O. Rocha, Leonardo H. F. de Lima, Lucas Bleicher and Raquel Cardoso de Melo-Minardi
    Citation: BMC Molecular and Cell Biology 2020 21:50
  27. Following the recent outbreak of the new coronavirus pandemic (Covid-19), the rapid determination of the structure of the homo-trimeric spike glycoprotein has prompted the study reported here. The aims were to...

    Authors: Elliot D. Drew and Robert W. Janes
    Citation: BMC Molecular and Cell Biology 2020 21:49
  28. Colorectal cancer (CRC) is a leading cancer and a major cause of death. Lipopolysaccharide (LPS), an abundant component in gut microbiome, is involved in CRC progression and metastasis, potentially through reg...

    Authors: Yimei Jiang, Xiaopin Ji, Kun Liu, Yiqing Shi, Changgang Wang, You Li, Tao Zhang, Yonggang He, Ming Xiang and Ren Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:48
  29. Chondrocytes are exposed to an inflammatory micro-environment in the extracellular matrix (ECM) of articular cartilage in joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). In OA, degene...

    Authors: Bernadette Jeremiasse, Csaba Matta, Christopher R. Fellows, David J. Boocock, Julia R. Smith, Susan Liddell, Floris Lafeber, Willem E. van Spil and Ali Mobasheri
    Citation: BMC Molecular and Cell Biology 2020 21:47
  30. Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of...

    Authors: Pierre Laville, Sandrine Fartek, Natacha Cerisier, Delphine Flatters, Michel Petitjean and Leslie Regad
    Citation: BMC Molecular and Cell Biology 2020 21:46
  31. Klotho is a multifunctional protein, which exists both in a membrane bound and a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response, and renal fibrosis, thus regulatio...

    Authors: Yan Li, Yong Liu, Kailong Wang, Yinghui Huang, Wenhao Han, Jiachuan Xiong, Ke Yang, Mingying Liu, Tangli Xiao, Chi Liu, Ting He, Xianjin Bi, Jingbo Zhang, Bo Zhang and Jinghong Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:45
  32. Trace elements function as essential cofactors that are involved in various biochemical processes in mammals. Autophagy is vital for nutrient supplement, which is an important Zeitegber for the circadian homeosta...

    Authors: Yicheng Jiang, Yang Gu, Hai Xu, Xiaoyi Tian, Xuefeng Zhang, Xiaojin Xu, Wenting Yan and Xiwen Zhang
    Citation: BMC Molecular and Cell Biology 2020 21:44
  33. Growth-temperature stress causes biochemical changes in the cells and reduction of biomass yield. Quantitative proteome of Arthrospira platensis C1 in response to low- and high temperature stresses was previously...

    Authors: Pavinee Kurdrid, Phutnichar Phuengcharoen, Jittisak Senachak, Sirilak Saree and Apiradee Hongsthong
    Citation: BMC Molecular and Cell Biology 2020 21:43
  34. Stress is an important cause of skin disease, including hair loss. The hormonal response to stress is due to the HPA axis, which comprises hormones such as corticotropin releasing factor (CRF), adrenocorticotr...

    Authors: Eun Young Lee, You Jin Nam, Sangjin Kang, Eun Ju Choi, Inbo Han, Jinwan Kim, Dong Hyun Kim, Ji Hae An, Sunghou Lee, Min Ho Lee and Ji Hyung Chung
    Citation: BMC Molecular and Cell Biology 2020 21:42
  35. Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart. However, the biological role of SP/NK1R ...

    Authors: Yun-Mi Jeong, Xian Wu Cheng, Kyung Hye Lee, Sora Lee, Haneul Cho and Weon Kim
    Citation: BMC Molecular and Cell Biology 2020 21:41
  36. In the poultry and livestock industries, precise genetic information is crucial for improving economic traits. Thus, functional genomic studies help to generate faster, healthier, and more efficient animal pro...

    Authors: Jeong Hyo Lee, Seo Woo Kim, Ji Seon Han, Seung Pyo Shin, Sang In Lee and Tae Sub Park
    Citation: BMC Molecular and Cell Biology 2020 21:40
  37. Members of the T-box family of DNA-binding proteins play a prominent role in the differentiation of the three primary germ layers. VegT, Brachyury, and Eomesodermin function as transcriptional activators and, ...

    Authors: Shoshana Reich, Peter Kayastha, Sushma Teegala and Daniel C. Weinstein
    Citation: BMC Molecular and Cell Biology 2020 21:39
  38. Detailed structural knowledge of enzyme-inhibitor complexes trapped in intermediate state is the key for a fundamental understanding of reaction mechanisms taking place in enzymes and is indispensable as a str...

    Authors: Peter Agback, Esmeralda Woestenenk and Tatiana Agback
    Citation: BMC Molecular and Cell Biology 2020 21:38
  39. To establish a metabolite fingerprint of ossification of the thoracic ligamentum flavum (OTLF) patients using liquid chromatography-mass spectrometry (LC-MS) in combination with transcriptomic data and explore...

    Authors: Jiahao Li, Lingjia Yu, Shigong Guo and Yu Zhao
    Citation: BMC Molecular and Cell Biology 2020 21:37
  40. The SMC5/6 complex, cohesin and condensin are the three mammalian members of the structural maintenance of chromosomes (SMC) family, large ring-like protein complexes that are essential for genome maintenance....

    Authors: András Horváth, Gergely Rona, Michele Pagano and Philip W. Jordan
    Citation: BMC Molecular and Cell Biology 2020 21:36
  41. Fluorescence microscopy is a powerful tool in cell biology, especially for the study of dynamic processes. Intensive irradiation of bacteria with UV, blue and violet light has been shown to be able to kill cel...

    Authors: Nina El Najjar, Muriel C. F. van Teeseling, Benjamin Mayer, Silke Hermann, Martin Thanbichler and Peter L. Graumann
    Citation: BMC Molecular and Cell Biology 2020 21:35
  42. Deficiency in thymidine kinase 2 (TK2) or p53 inducible ribonucleotide reductase small subunit (p53R2) is associated with tissue specific mitochondrial DNA (mtDNA) depletion. To understand the mechanisms of th...

    Authors: Liya Wang, Ren Sun and Staffan Eriksson
    Citation: BMC Molecular and Cell Biology 2020 21:33
  43. Neutral cholesterol ester hydrolase 1 (NCEH1) catalyzes the hydrolysis of cholesterol ester (CE) in macrophages. Genetic ablation of NCEH1 promotes CE-laden macrophages and the development of atherosclerosis i...

    Authors: Hiroshi Matsuoka, Riki Tokunaga, Miyu Katayama, Yuichiro Hosoda, Kaoruko Miya, Kento Sumi, Ami Ohishi, Jun Kamishikiryo, Akiho Shima and Akihiro Michihara
    Citation: BMC Molecular and Cell Biology 2020 21:32
  44. Cytoprotection afforded by mitochondrial ATP-sensitive K+-channel (mKATP-channel) opener diazoxide (DZ) largely depends on the activation of potassium cycle with eventual modulation of mitochondrial functions and...

    Authors: Olga Akopova, Liudmila Kolchinskaya, Valentina Nosar, Iryna Mankovska and Vadim Sagach
    Citation: BMC Molecular and Cell Biology 2020 21:31
  45. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its e...

    Authors: Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama and Klaus Ebnet
    Citation: BMC Molecular and Cell Biology 2020 21:30
  46. Low concentrations of tumor necrosis factor-alpha (TNF-α) and its receptor TNFR2 are both reported to promote osteogenic differentiation of osteoblast precursor cells. Moreover, low concentrations of TNF-α up-...

    Authors: Yu Zhang, Chengzhe Yang, Shaohua Ge, Limei Wang, Jin Zhang and Pishan Yang
    Citation: BMC Molecular and Cell Biology 2020 21:29
  47. Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently w...

    Authors: Bashar M. Thejer, Partho P. Adhikary, Sarah L. Teakel, Johnny Fang, Paul A. Weston, Saliya Gurusinghe, Ayad G. Anwer, Martin Gosnell, Jalal A. Jazayeri, Marina Ludescher, Lesley-Ann Gray, Michael Pawlak, Robyn H. Wallace, Sameer D. Pant, Marie Wong, Tamas Fischer…
    Citation: BMC Molecular and Cell Biology 2020 21:26
  48. Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hu...

    Authors: Nisha Venugopal, Ananga Ghosh, Hardik Gala, Ajoy Aloysius, Neha Vyas and Jyotsna Dhawan
    Citation: BMC Molecular and Cell Biology 2020 21:25

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